JNJ 10181457 dihydrochloride

Modify Date: 2024-01-13 00:43:43

JNJ 10181457 dihydrochloride structure	Common Name	JNJ 10181457 dihydrochloride
	CAS Number	544707-19-9	Molecular Weight	312.45
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₈N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JNJ 10181457 dihydrochloride

JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1].

Name	4-[[3-(4-piperidin-1-ylbut-1-ynyl)phenyl]methyl]morpholine

Description	JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vivo	JNJ 10181457 (1 mg/kg，i.v.) 在雄性 Wistar 大鼠中，相比于生理盐水对照组，可以阻断组胺 (50 μg/kg) 或甲硫美哌 (50 μg/kg) 产生的迷走神经诱发的心动过缓反应的抑制作用[1]。
References	[1]. Mónica García, et al. Pharmacological Evidence that Histamine H3 Receptors Mediate Histamine-Induced Inhibition of the Vagal Bradycardic Out-flow in Pithed Rats. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):113-21.

Molecular Formula	C₂₀H₂₈N₂O
Molecular Weight	312.45
Exact Mass	384.17400
PSA	15.71000
LogP	4.22610

DC Chemicals Limited
China
Product Name: JNJ 10181457
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: JNJ 10181457 dihydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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