2'-O-Methylguanosine

Modify Date: 2026-06-30 17:43:31

2'-O-Methylguanosine Structure
2'-O-Methylguanosine structure
 Common Name 2'-O-Methylguanosine
CAS Number 2140-71-8 Molecular Weight 297.267
Density 2.0±0.1 g/cm3 Boiling Point 711.7ºC at 760 mmHg
Molecular Formula C11H15N5O5 Melting Point 218-220ºC
MSDS N/A Flash Point 384.2ºC

 Use of 2'-O-Methylguanosine


2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2].

Summary: 2'-O-methylguanosine, also known as 2'-O-Methylguanosine, has a molecular formula of C11H15N5O5 and a molecular weight of 297.267, with a CAS number of 2140-71-8. It appears as a white solid with a熔点of 218-220ºC. For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2'-O-methylguanosine
Synonym More Synonyms

 2'-O-Methylguanosine Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2].
Related Catalog
References

[1]. B C Persson, et al. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res. 1997 Oct 15;25(20):4093-7.

[2]. T Mori, et al. Isolation and identification of apoptosis inducing nucleosides from CD57(+)HLA-DRbright natural suppressor cell line. Biochem Biophys Res Commun. 1998 Oct 20;251(2):416-22.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 2.0±0.1 g/cm3
Boiling Point 711.7ºC at 760 mmHg
Melting Point 218-220ºC
Molecular Formula C11H15N5O5
Molecular Weight 297.267
Flash Point 384.2ºC
Exact Mass 297.107330
PSA 148.51000
LogP -0.36
Vapour Pressure 2.93E-21mmHg at 25°C
Index of Refraction 1.829
Storage condition Refrigerator

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
HS Code 2934999090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 2'-O-MethylguanosineBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Inhibitory concentration against hepatitis C virus NS5B-mediated RNA synthesis in HBI...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL824929
Name: Inhibition HCV RNA replication
Source: ChEMBL
Target: RNA-directed RNA polymerase
External Id: CHEMBL691888
Name: Inhibition HCV NS5B-mediated RNA synthesis
Source: ChEMBL
Target: RNA-directed RNA polymerase
External Id: CHEMBL691889
Name: Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase
Source: ChEMBL
Target: N/A
External Id: CHEMBL2025703
Name: Effective concentration against hepatitis C virus RNA replication in a subgenomic bic...
Source: ChEMBL
Target: N/A
External Id: CHEMBL834418
Total 5, Current Page 1 of 1
1

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2'-methylguanosine
Gm19
2'-O-(TERT-BUTYLDIMETHYLSILYL)PACLITAXEL
UNII-W722H4PA1S
2'-O-Methylguanosine
Guanosine,2'-O-methyl
2'-O-Methyl Guanosine
2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-3H-purin-6-one
MFCD00057053
O2'-methyl-guanosine
2'-O-methyl-guanosine
2’-OMeGuanosine
2'-O-Methylguanosine Hydrate

 2'-O-Methylguanosine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the storage conditions for 2'-O-methylguanosine?
A: Storage conditions for 2'-O-methylguanosine: Refrigerator.
Q: What is the CAS number of 2'-O-methylguanosine?
A: CAS number of 2'-O-methylguanosine is 2140-71-8.
Q: What are the upstream materials of 2'-O-methylguanosine?
A: Related upstream materials(CAS) of 2'-O-methylguanosine: 80791-87-3;572912-50-6;194034-59-8;17287-03-5;118-00-3;194034-67-8;1061667-19-3;280-57-9;69304-44-5.
Q: What is the English name of 2'-O-methylguanosine?
A: The English name of 2'-O-methylguanosine is 2'-O-methylguanosine.
Q: What is the LogP of 2'-O-methylguanosine?
A: LogP of 2'-O-methylguanosine is -0.36.
Q: What is the molecular weight of 2'-O-methylguanosine?
A: Molecular weight of 2'-O-methylguanosine is 297.267.
Q: What are the uses of 2'-O-methylguanosine?
A: Main uses of 2'-O-methylguanosine: 2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2].
Q: What is the polar surface area (PSA) of 2'-O-methylguanosine?
A: Polar surface area (PSA) of 2'-O-methylguanosine is 148.51000.
Q: What is the safety information for 2'-O-methylguanosine?
A: Safety information for 2'-O-methylguanosine: 26-36.
Q: What is the melting point of 2'-O-methylguanosine?
A: Melting point of 2'-O-methylguanosine is 218-220ºC.

 2'-O-Methylguanosinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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