BCX 1470 (methanesulfonate)

Modify Date: 2024-01-20 12:43:29

BCX 1470 (methanesulfonate) Structure
BCX 1470 (methanesulfonate) structure
Common Name BCX 1470 (methanesulfonate)
CAS Number 217099-44-0 Molecular Weight 398.47700
Density N/A Boiling Point 509.9ºC at 760 mmHg
Molecular Formula C15H14N2O5S3 Melting Point N/A
MSDS N/A Flash Point 262.2ºC

 Use of BCX 1470 (methanesulfonate)


BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

 Names

Name 2-Thiophenecarboxylic acid 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester methanesulfonate (1:1)
Synonym More Synonyms

 BCX 1470 (methanesulfonate) Biological Activity

Description BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
Related Catalog
References

[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468

[2]. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8.

 Chemical & Physical Properties

Boiling Point 509.9ºC at 760 mmHg
Molecular Formula C15H14N2O5S3
Molecular Weight 398.47700
Flash Point 262.2ºC
Exact Mass 398.00600
PSA 195.40000
LogP 4.85090
Storage condition 2-8℃

 Synonyms

BCX 1470 methanesulfonate
BCX 1470 (methanesulfonate)
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