t-Boc-N-amido-PEG2-NHS ester

Modify Date: 2024-01-08 13:22:18

t-Boc-N-amido-PEG2-NHS ester Structure
t-Boc-N-amido-PEG2-NHS ester structure
Common Name t-Boc-N-amido-PEG2-NHS ester
CAS Number 2183440-73-3 Molecular Weight 374.39
Density N/A Boiling Point N/A
Molecular Formula C16H26N2O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of t-Boc-N-amido-PEG2-NHS ester


Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Boc-NH-PEG2-C2-NHS ester
Synonym More Synonyms

 t-Boc-N-amido-PEG2-NHS ester Biological Activity

Description Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C16H26N2O8
Molecular Weight 374.39

 Synonyms

MFCD31381627