t-Boc-N-amido-PEG3-thiol

Modify Date: 2024-01-09 18:46:42

t-Boc-N-amido-PEG3-thiol Structure
t-Boc-N-amido-PEG3-thiol structure
Common Name t-Boc-N-amido-PEG3-thiol
CAS Number 1895922-68-5 Molecular Weight 309.422
Density 1.1±0.1 g/cm3 Boiling Point 419.4±40.0 °C at 760 mmHg
Molecular Formula C13H27NO5S Melting Point N/A
MSDS N/A Flash Point 207.5±27.3 °C

 Use of t-Boc-N-amido-PEG3-thiol


Thiol-PEG3-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl (2-{2-[2-(2-sulfanylethoxy)ethoxy]ethoxy}ethyl)carbamate
Synonym More Synonyms

 t-Boc-N-amido-PEG3-thiol Biological Activity

Description Thiol-PEG3-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 419.4±40.0 °C at 760 mmHg
Molecular Formula C13H27NO5S
Molecular Weight 309.422
Flash Point 207.5±27.3 °C
Exact Mass 309.160980
LogP 1.10
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.472

 Synonyms

2-Methyl-2-propanyl (2-{2-[2-(2-sulfanylethoxy)ethoxy]ethoxy}ethyl)carbamate
MFCD29764342
Carbamic acid, N-[2-[2-[2-(2-mercaptoethoxy)ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester
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