N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)

Modify Date: 2024-01-02 22:20:17

N-BOC-2,2′-(ethylenedioxy)bis(ethylamine) Structure
N-BOC-2,2′-(ethylenedioxy)bis(ethylamine) structure
 Common Name N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)
CAS Number 153086-78-3 Molecular Weight 248.319
Density 1.0±0.1 g/cm3 Boiling Point 365.2±27.0 °C at 760 mmHg
Molecular Formula C11H24N2O4 Melting Point N/A
MSDS USA Flash Point 174.6±23.7 °C

 Use of N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)


PROTAC Linker 13 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 13 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name tert-butyl N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]carbamate
Synonym More Synonyms

  Biological Activity

Description PROTAC Linker 13 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 13 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl/ether

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 365.2±27.0 °C at 760 mmHg
Molecular Formula C11H24N2O4
Molecular Weight 248.319
Flash Point 174.6±23.7 °C
Exact Mass 248.173615
PSA 82.81000
LogP 0.19
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.460

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

 Articles4

More Articles
A modular cross-linking approach for exploring protein interactions.

J. Am. Chem. Soc. 125 , 2416 - 2425, (2003)

A method is described for the elucidation of protein-protein interactions using novel cross-linking reagents and mass spectrometry. The method incorporates (1) a modular solid-phase synthetic strategy...

Spinke, J., et al.

J. Phys. Chem. 99(9) , 7012-7019, (1993)

Sigal, G. B., et al.

J. Am. Chem. Soc. 118 , 3789-3800, (1996)

 Synonyms

CBZ-L-Asginine-OH Hydrochloride
AmbotzBNN1016
2-Methyl-2-propanyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate
N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)
Carbamic acid, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
N-Boc-3,6-dioxa-1,8-octanediamine
N-Boc-3,6-dioxaoctane-1,8-diamine
t-Boc-N-amido-PEG2-Amine
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Chemsrc provides CAS#:153086-78-3 MSDS, density, melting point, boiling point, structure, etc. Its name is N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)>> amp version: N-BOC-2,2′-(ethylenedioxy)bis(ethylamine)

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