IMM-01

Modify Date: 2024-01-12 00:10:54

IMM-01 Structure
IMM-01 structure
Common Name IMM-01
CAS Number 218795-74-5 Molecular Weight 267.35
Density N/A Boiling Point N/A
Molecular Formula C12H17N3O2S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of IMM-01


IMM-01 is a formin agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects[1].

 Names

Name N1-(tert-butyl)-2-(2,4-dihydroxybenzylidene)hydrazine-1-carbothioamide

 IMM-01 Biological Activity

Description IMM-01 is a formin agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects[1].
Related Catalog
References

[1]. L Leanne Lash, et al. Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells. Cancer Res. 2013 Nov 15;73(22):6793-803.  

 Chemical & Physical Properties

Molecular Formula C12H17N3O2S
Molecular Weight 267.35
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport
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