Clenbuterol hydrochloride structure
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Common Name | Clenbuterol hydrochloride | ||
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CAS Number | 21898-19-1 | Molecular Weight | 313.651 | |
Density | 1.25g/cm3 | Boiling Point | 404.9ºC at 760 mmHg | |
Molecular Formula | C12H19Cl3N2O | Melting Point | 174-175.5°C | |
MSDS | Chinese USA | Flash Point | 198.7ºC | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of Clenbuterol hydrochlorideClenbuterol hydrochloride (NAB-365 hydrochloride) is a β2 adrenergic receptor agonist. It is a powerful bronchodilator withfat burning properties. |
Name | clenbuterol hydrochloride |
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Synonym | More Synonyms |
Description | Clenbuterol hydrochloride (NAB-365 hydrochloride) is a β2 adrenergic receptor agonist. It is a powerful bronchodilator withfat burning properties. |
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Related Catalog | |
In Vitro | Clenbuterol increases lipolysis in rat primary adipocytes compared with control. Free glycerol release into the culture medium is 158% and 190% of control values in cultures containing 0.1, or 1 μM Clenbuterol, respectively[1]. |
In Vivo | Clenbuterol has been shown to decrease body fat in animals and can induce apoptosis in adipose tissue in mice[1]. In red and white muscles, Clenbuterol induces reductions in mitochondrial content, proteins involved in fatty acid transport oxidation, glucose transport, lactate transport, monocarboxylate transporter, and pyruvate oxidation. These extensive metabolic changes induced by Clenbuterol are associated with reductions in PGC-1α and increases in RIP140[2]. Repeated administration of the centrally acting beta adrenoceptor agonist, Clenbuterol, to rats reduces the ability of isoproterenol to increase the concentration of cyclic AMP (cAMP) in slices of cerebellum. This reduced responsiveness to isoproterenol is accompanied by a marked reduction in the density of beta adrenoceptors[3]. In normal soleus muscle, Clenbuterol treatment stimulates protein synthesis, inhibits Ca2+-dependent proteolysis, and increases the levels of calpastatin protein. On the other hand, the administration of Clenbuterol to DEN rats ameliorates the loss of muscle mass, enhances the rate of protein synthesis, attenuates hyperactivation of proteasomal and lysosomal proteolysis, and suppresses the transcription of the lysosomal protease cathepsin L and of atrogin-1/MAFbx and MuRF1[4]. |
Cell Assay | MTS assay is performed to determine the number of viable cells in culture. Cells are treated with 0 (vehicle only), 0.1, or 1 μM Clenbuterol for 6, 12, 24, or 48 h. The absorbance is measured at 490 nm in a plate reader determine the formazan concentration, which is proportional to the number of living cells in culture[1]. |
Animal Admin | Rats: Rats are randomly divided into two treatment groups. The control group is provided with standard chow and water ad libitum for 3 weeks, while the Clenbuterol group is provided with standard chow and treated for 3 weeks with Clenbuterol administered via the drinking water (30 mg Clenbuterol/L). Body weight and the amount of water consumed are recorded twice each week. After 3 wk, the animals are anesthetized and hindlimb muscles are excised[2]. |
References |
Density | 1.25g/cm3 |
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Boiling Point | 404.9ºC at 760 mmHg |
Melting Point | 174-175.5°C |
Molecular Formula | C12H19Cl3N2O |
Molecular Weight | 313.651 |
Flash Point | 198.7ºC |
Exact Mass | 312.056305 |
PSA | 58.28000 |
LogP | 4.77120 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | Missing Phrase - N15.00950417 |
Hazard Codes | T:Toxic |
Risk Phrases | R25 |
Safety Phrases | S22-S36/37/39-S45 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | DN3180000 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2922199020 |
HS Code | 2922199020 |
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Summary | 2922199020. VAT:17.0%. Tax rebate rate:9.0%. Supervision conditions:l(Drug import and export permit). MFN tariff:6.5%. General tariff:30.0% |
Mutagenicity and DNA-damaging potential of clenbuterol and its metabolite 4-amino-3,5-dichlorobenzoic acid in vitro.
Food Chem. Toxicol. 77 , 82-92, (2015) The aim of this study was to evaluate in vitro toxicity of clenbuterol and its metabolite 4-amino-3,5-dichlorobenzoic acid. Cytotoxicity and pro-oxidative effect of both compounds were studied on huma... |
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Detection of clenbuterol hydrochloride residuals in pork liver using a customized surface plasmon resonance bioanalyzer.
PLoS ONE 10(3) , e0122005, (2015) A surface plasmon resonance (SPR) immunoassay with an immobilization of self-assembled molecular identification membrane for the detection of residual Clenbuterol Hydrochloride (CLB) in pork liver was... |
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Study of interaction between agonists and asn293 in helix VI of human beta(2)-adrenergic receptor.
Mol. Pharmacol. 56 , 909, (1999) Previously, we demonstrated the involvement of Asn293 in helix VI of the human beta(2)-adrenergic receptor in stereoselective agonist recognition and activation. In the present study, we have further ... |
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