Lyn peptide inhibitor TFA

Modify Date: 2025-08-25 13:08:52

Lyn peptide inhibitor TFA Structure
Lyn peptide inhibitor TFA structure
Common Name Lyn peptide inhibitor TFA
CAS Number 222018-18-0 Molecular Weight 2370.878
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C115H184N30O24 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lyn peptide inhibitor TFA


Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of  asthma, allergic, and other eosinophilic disorders[1].

 Names

Name N-Stearoyl-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl-L-prolinamide
Synonym More Synonyms

 Lyn peptide inhibitor TFA Biological Activity

Description Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of  asthma, allergic, and other eosinophilic disorders[1].
Related Catalog
Target

IC50: Lyn kinase[1]

References

[1]. T Adachi, et al. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J Immunol. 1999 Feb 1;162(3):1496-501.

[2]. T Adachi, et al. A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J Immunol. 1999 Jul 15;163(2):939-46.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C115H184N30O24
Molecular Weight 2370.878
Exact Mass 2369.409912
LogP 4.55
Index of Refraction 1.648

 Safety Information

Hazard Codes Xi

 Synonyms

L-Prolinamide, N-(1-oxooctadecyl)-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl-
N-Stearoyl-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl-L-prolinamide
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