Ginsenoside Rg1

Modify Date: 2024-01-02 18:36:44

Ginsenoside Rg1 Structure
Ginsenoside Rg1 structure
 Common Name Ginsenoside Rg1
CAS Number 22427-39-0 Molecular Weight 801.013
Density 1.3±0.1 g/cm3 Boiling Point 898.5±65.0 °C at 760 mmHg
Molecular Formula C42H72O14 Melting Point 194～197 ℃
MSDS Chinese USA Flash Point 497.2±34.3 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Ginsenoside Rg1


Ginsenoside Rg1 is one of the major active components of ginseng. Ginsenoside Rg1 displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

 Names

Name ginsenoside Rg1
Synonym More Synonyms

 Ginsenoside Rg1 Biological Activity

Description Ginsenoside Rg1 is one of the major active components of ginseng. Ginsenoside Rg1 displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.
Related Catalog
Target

Aβ1-42

p65

In Vitro Ginsenoside Rg1 promotes the proliferation and differentiation of human dental pulp cells (hDPCs). The proliferative ability of hDPCs in Ginsenoside Rg1 is significantly enhanced (p<0.05), especially in the Ginsenoside Rg1 (5 μM) group. ALP activity and gene expressions of DSPP and DMP1 are increased in the induction group, Ginsenoside Rg1 group, and their combination group compared with the control group (p<0.05)[3]. In the RAW264.7 cells stimulated by lipopolysaccharides (LPS) , the level of p-IκBα and p-p65 is significantly higher than in controls and PPAR-γ levels are significantly lower. Treatment with Rg1 vitro inhibits IκBα phosphorylation, reduces NF-κB nuclear translocation and upregulates PPAR-γ expression[2].
In Vivo In the inflamed joints of adjuvant-induced arthritis (AIA) rats, the level of p-IκBα and p-p65 is significantly higher than in controls and PPAR-γ levels are significantly lower. Treatment with Ginsenoside Rg1 in vivo inhibits IκBα phosphorylation, reduces NF-κB nuclear translocation and upregulates PPAR-γ expression[2]. Ginsenoside Rg1 (G-Rg1) and Ginsenoside Rg2 (G-Rg2) reduce the escape latencies on the last two training days compared to the Alzheimer's disease (AD) model group (p<0.05). In the spatial exploration test, the total time spent in the target quadrant and the number of mice that exactly crossed the previous position of the platform are clearly shorter and lower, respectively, in the AD model group mice than in the normal control group mice (p<0.01), a trend that is reversed by treatment with Ginsenoside Rg1 and Ginsenoside Rg2 (Ginsenoside Rg1, p<0.01; Ginsenoside Rg2, p<0.05). Treatment with Ginsenoside Rg1 and Ginsenoside Rg2 effectively improve cognitive function of the mice that have declined due to AD. Ginsenoside Rg1 and Ginsenoside Rg2 reduce Aβ1-42 accumulation in APP/PS1 mice. In the Ginsenoside Rg1 and Ginsenoside Rg2 treated mice, the pathological abnormalities observed in the APP/PS1 mice are gradually ameliorated. Clear nucleoli and light brown, sparsely scattered Aβ deposits are visible[1].
Cell Assay hDPCs are incubated with different concentrations of Ginsenoside Rg1 (0.1, 0.5, 2.5, 5, 10 and 20 μM) . The effects of Ginsenoside Rg1 on the proliferative ability of hDPCs are evaluated by a fibroblast colony forming test, MTT assay and flow cytometry for cell cycle. The control group, osteogenic induction group, Ginsenoside Rg1 (5 μM) group and combination group are designed, and alkaline phosphatase (ALP) activity and FQ-PCR for gene expressions of dentine sialophosphoprotein (DSPP) and dentine matrix protein 1 (DMP1) are performed to evaluate the differentiation of hDPCs[3].
Animal Admin Mice[1] Male APP/PS1 mice, weighing 20±2 g, and male C57BL/6J mice, weighing 20±2 g, are used. The animals are maintained in an air-conditioned animal center at 23±2°C and a relative humidity of 50±10%, with a natural light-dark cycle. Food and water are available ad libitum. After acclimatization for 1 wk, the mice are divided into four groups (n=10 in each group): the normal control group, the AD model group, the Ginsenoside Rg1 group, and the Ginsenoside Rg2 group. According to the concentration-response curves, the mice in the Ginsenoside Rg1 and Ginsenoside Rg2 groups are injected intraperitoneally once daily with Ginsenoside Rg1 and Ginsenoside Rg2 (30 mg/kg), respectively, dissolved in saline. The mice in the AD model group (APP/PS1 mice) and the normal control group (C57BL/6J nontransgenic littermates) are treated with isodose saline (0.9% w/v). All mice are treated for 1 mo before brain metabolite profiling.
References

[1]. Li N, et al. A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease. J Ginseng Res. 2016 Jan;40(1):9-17.

[2]. Zhang L, et al. Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-γ/NF-κB signal pathway. Oncotarget. 2017 Jul 24;8(33):55384-55393.

[3]. Wang P, et al. Effect of ginsenoside Rg1 on proliferation and differentiation of human dental pulp cells in vitro. Aust Dent J. 2012 Jun;57(2):157-65.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 898.5±65.0 °C at 760 mmHg
Melting Point 194～197 ℃
Molecular Formula C42H72O14
Molecular Weight 801.013
Flash Point 497.2±34.3 °C
Exact Mass 800.492188
PSA 239.22000
LogP 1.66
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.602

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LY9537200
CHEMICAL NAME :
Ginsenoside RG1
CAS REGISTRY NUMBER :
22427-39-0
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C42-H72-O14
MOLECULAR WEIGHT :
801.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
405 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,343,1975

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases 2-45
RIDADR UN 1230 3/PG 2
WGK Germany 3.0
RTECS LY9537200

 Synthetic Route

Ginsenoside Re structure

Ginsenoside Re

CAS#:52286-59-6

~%

Ginsenoside Rg1 Structure

Ginsenoside Rg1

CAS#:22427-39-0

Literature: EP2570132 A2, ; Paragraph 0049; 0050; 0051 ;
6-O-[6-O-acetyl-β-D-glucopyranosyl]-20-O-(β-D-glucopyranosyl)-20(S)-protopanaxatriol structure

6-O-[6-O-acetyl...

CAS#:163403-91-6

~%

Ginsenoside Rg1 Structure

Ginsenoside Rg1

CAS#:22427-39-0

Literature: Zou, Kun; Zhu, Shu; Tohda, Chihiro; Cai, Shaoqing; Komatsu, Katsuko Journal of Natural Products, 2002 , vol. 65, # 3 p. 346 - 351
Ginsenoside Re structure

Ginsenoside Re

CAS#:52286-59-6

~%

Alpha-L-Rhamnopyranose structure

Alpha-L-Rhamnop...

CAS#:6014-42-2

Ginsenoside Rg1 Structure

Ginsenoside Rg1

CAS#:22427-39-0

Literature: Planta Medica, , vol. 69, # 3 p. 285 - 286

 Preparation


 Articles35

More Articles
Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers.

BMC Genomics 16 , 159, (2015)

P. vietnamensis var. fuscidiscus, called "Yesanqi" in Chinese, is a new variety of P. vietnamensis, which was first found in Jinping County, the southern part of Yunnan Province, China. Compared with ...

[Cultivation of Panax ginseng adventitious roots in bubble bioreactors].

Zhongguo Zhong Yao Za Zhi 37(24) , 3706-11, (2012)

To study cultivation of Panax ginseng adventitious roots in bubble bioreactors.The adventitious roots were obtained through tissue culture different types of bioreactors. The contents of ginsenosides ...

Th1 immunity induction by ginsenoside Re involves in protection of mice against disseminated candidiasis due to Candida albicans.

Int. Immunopharmacol. 14(4) , 481-6, (2012)

Type-1 and -2 responses of T helper lymphocytes demonstrate essentially different and opposite effector functions. In the present study, we determined the immunoregulatory effect of ginsenoside Re aga...

 Synonyms

(2R,3R,4S,5S,6R)-2-({(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-pentaméthyl-17-[(2S)-6-méthyl-2-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-5-heptèn-2-yl]hexadécahydro-1H-cyclopenta[a]phénanthrén-6-yl}oxy)-6-(hydroxyméthyl)tétrahydro-2H-pyran-3,4,5-triol
GINSENOSIDE RGL
PANAXOSIDE A
Ginsenoside Rg1
EINECS 244-989-9
MFCD00210293
ginsenoside-Rg2
(3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl β-D-glucopyranoside
panaxosiderg1
(2R,3R,4S,5S,6R)-2-({(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-5-hepten-2-yl]hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl}oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
(3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl-β-D-glucopyranoside
Gensenoside Rg1
ginsenosidea2
GinsenosideRg1
Rg1
β-D-Glucopyranoside, (3β,6α,12β)-20-(β-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl
SANCHINOSIDE C1
ginsenosideg1
ginsinoside Rg1
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Ginsenoside Rg1 suppliers

Price: $127/10mM*1mLinDMSO

Reference only. check more Ginsenoside Rg1 price

Related Compounds: More...
6'-O-acetyl-ginsenoside Rg1
163403-91-6
Ginsenoside Rh8
343780-69-8
Ginsenoside Rh1
63223-86-9
Ginsenoside Rk3
364779-15-7
ginsenoside La
123617-34-5
Ginsenoside Rg3
11019-45-7
ginsenoside B
79104-62-4
Ginsenoside Rh3
105558-26-7
Ginsenoside Ra3
90985-77-6
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
S-(4-Methylphenyl) 2,2,2-trichloroethanethioate
56956-67-3
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
5-(2,4-Dichlorophenyl)-3-methylisoxazole
457654-05-6
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
N,N-Dipropyl-1,3,4-thiadiazole-2,5-diamine
71125-54-7
Chemsrc provides Ginsenoside Rg1(CAS#:22427-39-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ginsenoside Rg1 are included as well.>> amp version: Ginsenoside Rg1

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved