NaV1.7 inhibitor 51
Modify Date: 2024-01-27 07:20:02
NaV1.7 inhibitor 51 structure
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Common Name | NaV1.7 inhibitor 51 | ||
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| CAS Number | 2244153-85-1 | Molecular Weight | 499.512 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H20F3N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NaV1.7 inhibitor 51NaV1.7 inhibitor 51 is a highly potent, selective, orally active NaV1.7 inhibitor with IC50 of 10.7 nM in FLIPR membrane potential assay, no significant activity against NaV1.5 (IC50>10 uM).NaV1.7 inhibitor 51 shows good selectivity against other NaV isoforms and minimal inhibition at 10 uM for the resting state across different NaV isoforms.NaV1.7 inhibitor 51 exhibits state-dependent block of human, monkey, and mouse NaV1.7 with a similar potency range.NaV1.7 inhibitor 51 shows significant effects on the CCI-induced neuropathic pain model. |
| Name | NaV1.7 inhibitor 51 |
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| Description | NaV1.7 inhibitor 51 is a highly potent, selective, orally active NaV1.7 inhibitor with IC50 of 10.7 nM in FLIPR membrane potential assay, no significant activity against NaV1.5 (IC50>10 uM).NaV1.7 inhibitor 51 shows good selectivity against other NaV isoforms and minimal inhibition at 10 uM for the resting state across different NaV isoforms.NaV1.7 inhibitor 51 exhibits state-dependent block of human, monkey, and mouse NaV1.7 with a similar potency range.NaV1.7 inhibitor 51 shows significant effects on the CCI-induced neuropathic pain model. |
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| References | 1. Vidya Ramdas, et al. J Med Chem. 2020 Jun 11;63(11):6107-6133. |
| Molecular Formula | C24H20F3N5O2S |
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| Molecular Weight | 499.512 |