nAChR agonist CMPI hydrochloride
Modify Date: 2024-01-10 19:33:17
nAChR agonist CMPI hydrochloride structure
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Common Name | nAChR agonist CMPI hydrochloride | ||
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| CAS Number | 2250025-94-4 | Molecular Weight | 379.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H20Cl2N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of nAChR agonist CMPI hydrochloridenAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity[1][2]. |
| Name | nAChR agonist CMPI hydrochloride |
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| Description | nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity[1][2]. |
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| Related Catalog | |
| Target |
nAChR[1] |
| In Vitro | CMPI (0.01-10 µM) potentiates (α4)3(β2)2 (low ACh sensitivity) but not (α4)2(β2)3 (high ACh sensitivity) nAChRs in Xenopus laevis oocytes[1]. CMPI (0.01-10 µM) inhibits (α4)2(β2)3, human muscle and Torpedo nAChRs with IC50s of 0.6, 0.7 and 0.2 µM, respectively in Xenopus oocytes[1]. |
| References |
| Molecular Formula | C18H20Cl2N4O |
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| Molecular Weight | 379.28 |