(D)-(-)-α-4-hydroxyphenyl glycine

Modify Date: 2024-01-02 17:59:58

(D)-(-)-α-4-hydroxyphenyl glycine Structure
(D)-(-)-α-4-hydroxyphenyl glycine structure
Common Name (D)-(-)-α-4-hydroxyphenyl glycine
CAS Number 22818-40-2 Molecular Weight 167.162
Density 1.4±0.1 g/cm3 Boiling Point 365.8±32.0 °C at 760 mmHg
Molecular Formula C8H9NO3 Melting Point 240 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 175.0±25.1 °C

 Use of (D)-(-)-α-4-hydroxyphenyl glycine


D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].

 Names

Name D-4-hydroxyphenylglycine
Synonym More Synonyms

 (D)-(-)-α-4-hydroxyphenyl glycine Biological Activity

Description D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].
Related Catalog
References

[1]. Yu H, et al. Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii. Folia Microbiol (Praha). 2009;54(6):509-515.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 365.8±32.0 °C at 760 mmHg
Melting Point 240 °C (dec.)(lit.)
Molecular Formula C8H9NO3
Molecular Weight 167.162
Flash Point 175.0±25.1 °C
Exact Mass 167.058243
PSA 83.55000
LogP 0.20
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.633
Water Solubility 5 g/L (20 ºC)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29225000

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

(D)-(-)-α-4-hydroxyphenyl glycine
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine
D(-)-2-amino-(4-hydroxyphenyl)acetic acid
(R)-2-(4-Hydroxyphenyl)glycine
(2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid,4-Hydroxy-D-phenylglycine,Cefadroxyl impurity A
D(-)-4-Hydroxyphenylglycine
Benzeneacetic acid, α-amino-4-hydroxy-, (αR)-
(2R)-2-Amino-2-(4
D-N-(4-Hydroxyphenyl)glycine
(2R)-Amino(4-hydroxyphenyl)acetic acid
D(-)-2-(4-hydroxyphenyl)glycine
(R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic acid
EINECS 245-247-7
MFCD00004262
(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid
H-D-Phg(4-OH)-OH
(R)-2-Amino-2-(4-hydroxyphenyl)acetic acid
D-(-)-2-(4-Hydroxyphenyl)glycine
4-Hydroxy-D-phenylglycine
4-Hydroxy-D-(-)-2-phenylglycine
(D)-(-)-Alfa-4-hydroxyphenyl glycine
(R)-para-hydroxyphenylglycine
Amoxicillin Impurity 8
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