MEK/PI3K-IN-1

Modify Date: 2024-01-09 23:12:24

MEK/PI3K-IN-1 Structure
MEK/PI3K-IN-1 structure
 Common Name MEK/PI3K-IN-1
CAS Number 2281803-28-7 Molecular Weight 913.63
Density N/A Boiling Point N/A
Molecular Formula C36H37F5IN9O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MEK/PI3K-IN-1


MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].

 Names

Name MEK/PI3K-IN-1

 MEK/PI3K-IN-1 Biological Activity

Description MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].
Related Catalog
Target

MEK1:124 ± 11 nM (IC50)

PI3Kα:130 ± 13 nM (IC50)

PI3Kδ:236 ± 29 nM (IC50)

PI3Kβ:1537 ± 188 nM (IC50)

PI3Kγ:2745 ± 485 nM (IC50)

References

[1]. Van Dort ME, et al. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors. Eur J Med Chem. 2022 Feb 5;229:113996.

 Chemical & Physical Properties

Molecular Formula C36H37F5IN9O6
Molecular Weight 913.63
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Chemsrc provides MEK/PI3K-IN-1(CAS#:2281803-28-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of MEK/PI3K-IN-1 are included as well.>> amp version: MEK/PI3K-IN-1

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