Pomalidomide-amido-C1-Br
Modify Date: 2024-01-08 19:38:00
Pomalidomide-amido-C1-Br structure
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Common Name | Pomalidomide-amido-C1-Br | ||
|---|---|---|---|---|
| CAS Number | 2351106-38-0 | Molecular Weight | 394.18 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H12BrN3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Pomalidomide-amido-C1-BrPomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1]. |
| Name | Pomalidomide-amido-C1-Br |
|---|
| Description | Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | Pomalidomide-amido-C1-Br (Compound 6) can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (Compound 2). PROTAC B-Raf degrader 1 can effectively kill cancer cells via inducing cells apoptosis. As a B-Raf degrader, PROTAC B-Raf degrader 1 can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system, and further affects the expression of Mcl-1, a downstream protein of B-Raf[1]. |
| References |
| Molecular Formula | C15H12BrN3O5 |
|---|---|
| Molecular Weight | 394.18 |
| Storage condition | 2-8°C |