(±)-trans-GK563
Modify Date: 2024-01-13 22:06:43
(±)-trans-GK563 structure
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Common Name | (±)-trans-GK563 | ||
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| CAS Number | 2351820-19-2 | Molecular Weight | 246.345 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 364.2±11.0 °C at 760 mmHg | |
| Molecular Formula | C16H22O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 152.3±16.7 °C | |
Use of (±)-trans-GK563GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes[1]. |
| Name | (±)-trans-GK563 |
|---|---|
| Synonym | More Synonyms |
| Description | GK563 is a selective Ca2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes[1]. |
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| Related Catalog | |
| Target |
IC50: 1 nM (GVIA iPLA2), 22 μM (GVIA cPLA2)[1] |
| In Vitro | GK563 (0.091 M) inhibits the activity of 100% GVIA iPLA2, 88% GVIA cPLA2 and 25% GV sPLA2[1]. GK563 (0-0.1 μM) inhibits GVIA iPLA2 with a XI(50) value of 0.0000021 and inhibits GVIA cPLA2 with an IC50 value of 22 μM[1]. GK563 (0-0.1 μM) shows a better inhibitory effect than fluoroketone FKGK18 to GVIA iPLA2 with an IC50 value of 1 nM[1]. GK563 (0-0.1 μM; 16 h) reduces β-cell apoptosis induced by proinflammatory cytokines[1]. Apoptosis Analysis[1] Cell Line: β-cell line Concentration: 0.1-10 μM Incubation Time: 16 h Result: Promoted a slight but modest rise in cell death when worked alone, but produced a concentration-dependent inhibition of β-cell apoptosis by the co-treatment of cells with cytokines. |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 364.2±11.0 °C at 760 mmHg |
| Molecular Formula | C16H22O2 |
| Molecular Weight | 246.345 |
| Flash Point | 152.3±16.7 °C |
| Exact Mass | 246.161987 |
| LogP | 3.70 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.507 |
| (±)-trans-GK563 |
| (3S,4S)-3-(4-Phenylbutyl)-4-propyl-2-oxetanone |
| 2-Oxetanone, 3-(4-phenylbutyl)-4-propyl-, (3S,4S)- |