[Arg14,Lys15] Nociceptin structure
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Common Name | [Arg14,Lys15] Nociceptin | ||
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CAS Number | 236098-40-1 | Molecular Weight | 1909.16000 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C82H137N31O22 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of [Arg14,Lys15] Nociceptin[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP (ORL1; OP4), μ, δ and κ receptors, respectively[1]. |
Name | [Arg14,Lys15]Nociceptin |
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Synonym | More Synonyms |
Description | [Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP (ORL1; OP4), μ, δ and κ receptors, respectively[1]. |
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Related Catalog | |
In Vitro | [Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2]. |
In Vivo | In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2]. |
References |
Molecular Formula | C82H137N31O22 |
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Molecular Weight | 1909.16000 |
Exact Mass | 1908.06000 |
PSA | 919.32000 |
LogP | 1.29430 |
Safety Phrases | 22-24/25 |
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WGK Germany | 3 |
phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-arg-lys-asn-gln |