[Arg14,Lys15] Nociceptin

Modify Date: 2025-11-26 15:45:25

[Arg14,Lys15] Nociceptin structure	Common Name	[Arg14,Lys15] Nociceptin
	CAS Number	236098-40-1	Molecular Weight	1909.16000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈₂H₁₃₇N₃₁O₂₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of [Arg14,Lys15] Nociceptin

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP (ORL1; OP4), μ, δ and κ receptors, respectively[1].

Name	[Arg14,Lys15]Nociceptin
Synonym	More Synonyms

Description	[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP (ORL1; OP4), μ, δ and κ receptors, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vitro	[Arg14,Lys15]Nociceptin is about 30-fold more potent than Nociceptin (NC) and produces longer lasting effects[2].
In Vivo	In in vivo experiments, [Arg14,Lys15]Nociceptin mimics the effects of NC, producing, after intracerebroventricular administration, pronociceptive effects in the tail-withdrawal assay and inhibiting the locomotor activity of the mice[2].
References	[1]. Okada K, Sujaku T, Chuman Y, et al. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem Biophys Res Commun. 2000;278(2):493-498. [2]. Rizzi D, Rizzi A, Bigoni R, et al. [Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J Pharmacol Exp Ther. 2002;300(1):57-63.

Molecular Formula	C₈₂H₁₃₇N₃₁O₂₂
Molecular Weight	1909.16000
Exact Mass	1908.06000
PSA	919.32000
LogP	1.29430
InChIKey	VULLMZOQBGUKAT-VUXBHJHDSA-N
SMILES	CC(NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccccc1)C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCC(N)=O)C(=O)O