EG-011
Modify Date: 2024-04-05 19:48:55
EG-011 structure
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Common Name | EG-011 | ||
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| CAS Number | 2377113-41-0 | Molecular Weight | 482.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H26N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EG-011EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas[1][2][3]. |
| Name | EG-011 |
|---|
| Description | EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas[1][2][3]. |
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| Related Catalog | |
| In Vitro | EG-011 (500 nM, 2 μM; 72 小时) 在淋巴瘤细胞系 (OCI-LY-19 和 REC1) 中引起剂量依赖性细胞死亡增加 (20-55%)。EG-011 (1, 10 mM; for 24, 48 小时) 对正常的 PBMC 没有细胞毒性[1]。 EG-011 (500 nM, 5 μM; 24 小时) 导致 EG-011 敏感 (VL51) 而不是耐药 (Z138) 细胞系在 4、8 和 24 小时两种浓度下的肌动蛋白聚合增加[2] 。 |
| In Vivo | EG-011 (200 mg/kg; 腹腔注射; 每周 5 天) 延迟带有 MCL REC-1 细胞的雌性 NOD-SCID 小鼠的肿瘤生长 (第 6 天、第 7 天、第 9 天) 和肿瘤重量，肿瘤比对照小 2.2 倍 (P<0.001)[1]。 |
| References |
| Molecular Formula | C28H26N4O4 |
|---|---|
| Molecular Weight | 482.53 |