BAY-3827

Modify Date: 2024-01-06 20:55:26

BAY-3827 structure	Common Name	BAY-3827
	CAS Number	2377576-35-5	Molecular Weight	468.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₅FN₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BAY-3827

BAY-3827 is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 µM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1].

Name	BAY-3827
Synonym	More Synonyms

Description	BAY-3827 is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 µM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1].
Related Catalog	Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Target	IC50: 1.4 nM (AMPK kinase,10 µM ATP), 15 nM (AMPK kinase, 2 mM ATP), 1324 nM (Aurora A), 124 nM (Flt3), 788 nM (c-Met), 36 nM (Rsk4)[1]
In Vitro	BAY-3827 (0-200 μM) inhibits AMPK kinase activity with IC50 values of 1.4 nM at low, 10 µM ATP concentration and 15 nM at high, 2 mM ATP concentration[1]. BAY-3827 (0-200 μM) inhibits Aurora A, Flt3, c-Met and Rsk4 with IC50 values of 1324, 124, 788 and 36 nM , respectively with 10 µM ATP concentration[1]. BAY-3827 (overnight) strongly reduces ACC1 Ser79 phosphorylation in LNCaP and VCaP cells, and shows a lesser extent in IMR-32 and especially in Colo320 cells[1]. BAY-3827 (0-10 nM; 6 d) shows strong inhibitory effects to LNCaP and VCaP cells[1]. BAY-3827 (1 and 5 μM; 24 and 48 h) represses LIPE gene expression, reduces serine/threonine kinase AKT3 and blocks the expression of several genes from the mitochondrial carnitine palmitoyltransferase (CPT) family which is involved in acyl carnitine formation in VCaP cells[1]. BAY-3827 (5 μM; 2-4 d) significantly increases the formation of lipid droplets in comparison to androgen treatment only[1]. Cell Proliferation Assay[1] Cell Line: LNCaP, VCaP, 22Rv1, C4-2B, PC-3 and DU-145 prostate cancer cell lines Concentration: 0-10 nM Incubation Time: 6 d Result: Showed strong inhibitory effects for LNCaP and VCaP cells, two prostate cancer cell lines with IC50 values of 0.28 and 1.71 nM, respectily. Inhibited proliferation of 22Rv1 cells with an IC50 value of 5.55 nM.
References	[1]. Lemos C, et al. The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models. Cell Oncol (Dordr). 2021 Jun;44(3):581-594.

Molecular Formula	C₂₇H₂₅FN₆O
Molecular Weight	468.53

Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BAY-3827
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
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DC Chemicals Limited
China
Product Name: BAY-3827
Price: ￥750.0/5mg
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: BAY-3827
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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Price: ￥1550/10 mM * 1 mL in DMSO

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BAY-3827

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