KB02-SLF
Modify Date: 2023-02-03 11:34:12
KB02-SLF structure
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Common Name | KB02-SLF | ||
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| CAS Number | 2384184-40-9 | Molecular Weight | 949.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C50H65ClN4O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KB02-SLFKB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF. |
| Name | KB02-SLF |
|---|
| Description | KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF. |
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| Molecular Formula | C50H65ClN4O12 |
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| Molecular Weight | 949.52 |
| Hazard Codes | Xi |
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