MYF-01-37
Modify Date: 2024-01-02 17:53:58
MYF-01-37 structure
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Common Name | MYF-01-37 | ||
|---|---|---|---|---|
| CAS Number | 2416417-65-5 | Molecular Weight | 298.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H17F3N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MYF-01-37MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction[1]. |
| Name | MYF-01-37 |
|---|
| Description | MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction[1]. |
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| Related Catalog | |
| In Vitro | MYF-01-37 (10 μM; 24h) results in inhibition of direct YAP/TEAD interaction in HEK 293T cells, and in the reduction in canonical YAP target gene CTGF expression in PC-9 cells[1]. MYF-01-37 (0.1, 1, 10, 100 μM) has minimal impact on cell viability of several EGFR-mutant NCSLC cell lines[1]. MYF-01-37 (10 μM; 10 days) combinated with OT (combination of osimertinib and trametinib) leads to a dramatic decrease in dormant cells compared to OT alone[1]. |
| References |
| Molecular Formula | C15H17F3N2O |
|---|---|
| Molecular Weight | 298.30 |
| Storage condition | -20°C |