CXCR4 modulator-2

Modify Date: 2024-01-16 17:15:05

CXCR4 modulator-2 structure	Common Name	CXCR4 modulator-2
	CAS Number	2488943-55-9	Molecular Weight	428.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₃₂N₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CXCR4 modulator-2

CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model[1].

Name	CXCR4 modulator-2

Description	CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4:1.25 nM (IC50)
In Vivo	CXCR4 modulator-2 (10 mg/kg; IP; single dosage) significantly reduces the edema weights (∼50%) in the lesion and decreases the expression of CXCR4s[1]. Animal Model: male nude mice (6 weeks, 20 g; subcutaneous injection of 50 μL of λ-carrageenan)[1] Dosage: 10 mg/kg Administration: IP; single dosage Result: Significantly reduced the edema weights (∼50%) in the lesion and decreased the expression of CXCR4s.
References	[1]. Oum YH, et al. Discovery of novel aminopiperidinyl amide CXCR4 modulators through virtual screening and rational drug design. Eur J Med Chem. 2020;201:112479.

Molecular Formula	C₂₁H₃₂N₈O₂
Molecular Weight	428.53

CXCR4 modulator-2

Use of CXCR4 modulator-2

Names

CXCR4 modulator-2 Biological Activity

Chemical & Physical Properties