acetyl-dl-carnitine hydrochloride

Modify Date: 2024-01-05 14:03:11

acetyl-dl-carnitine hydrochloride Structure
acetyl-dl-carnitine hydrochloride structure
Common Name acetyl-dl-carnitine hydrochloride
CAS Number 2504-11-2 Molecular Weight 239.69700
Density N/A Boiling Point N/A
Molecular Formula C9H18ClNO4 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of acetyl-dl-carnitine hydrochloride


(±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) is a weak cholinergic agonist with cholinergic properties. (±)-Acetylcarnitine chloride is an important intermediate in lipid metabolism[1][2].

 Names

Name (2-acetyloxy-3-carboxypropyl)-trimethylazanium,chloride
Synonym More Synonyms

 acetyl-dl-carnitine hydrochloride Biological Activity

Description (±)-Acetylcarnitine chloride (Acetyl dl-carnitine chloride) is a weak cholinergic agonist with cholinergic properties. (±)-Acetylcarnitine chloride is an important intermediate in lipid metabolism[1][2].
Related Catalog
In Vitro Large increases of Acetylcarnitine concentration during the flight of the blowfly and the presence of an active Acetylcarnitine transferase indicate that Acetylcarnitine is important in carbohydrate metabolism. Acetylcarnitine has been synthesized by the choline acetylase system isolated from brain tissue and is destroyed by cholinesterase[2].
In Vivo In rats, the infusion of 2 mg (±)-Acetylcarnitine chloride decreases blood flow through the hind limb vasculature 50%. (±)-Acetylcarnitine chloride also potentiates the inhibitory effect of adrenaline on the isolated rabbit duodenum[3].
References

[1]. R A Chalmers, et al. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. Pediatr Res. 1984 Dec;18(12):1325-8.

[2]. R L Sass, et al. Acetylcarnitine: on the relationship between structure and function. Biochem Biophys Res Commun. 1973 Dec 10;55(3):736-42.

[3]. R T Louis-Ferdinand, et al. Flow decrease through rat hind limb vasculature by (plus or minus)-carnitine, (plus or minus)-acetylcarnitine and (plus or minss)-chloroacetylcarnitine chlorides. J Pharm Pharmacol. 1970 Sep;22(9):704-5.

 Chemical & Physical Properties

Molecular Formula C9H18ClNO4
Molecular Weight 239.69700
Exact Mass 239.09200
PSA 63.60000
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BP2979200
CHEMICAL NAME :
Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, chloride, acetate, (+-)-
CAS REGISTRY NUMBER :
2504-11-2
LAST UPDATED :
198912
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H17-N-O4.Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7400 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959

 Safety Information

RIDADR NONH for all modes of transport
WGK Germany 3
RTECS BP2979200

 Precursor & DownStream

Precursor  0

DownStream  1

 Articles4

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Photoaffinity labelling of carnitine acetyltransferase with S-(p-azidophenacyl)thiocarnitine.

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 Synonyms

rac. Acetylcarnitinchlorid
Acetylcarnitin-chlorid
rac. Acetyl-carnithin
EINECS 219-709-3
O-Acetylcarnitinhydrochlorid
Acetyl dl-carnitine chloride
MFCD00080826
Evans Blue tetrasodium salt
Acetyl-DL-carnitine hydrochloride
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