DL-Carnitine hydrochloride

Modify Date: 2024-01-02 09:50:30

DL-Carnitine hydrochloride structure	Common Name	DL-Carnitine hydrochloride
	CAS Number	461-05-2	Molecular Weight	197.660
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇H₁₆ClNO₃	Melting Point	190-205ºC
	MSDS	USA	Flash Point	N/A

Use of DL-Carnitine hydrochloride

(±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.

Name	carnitinamide chloride
Synonym	More Synonyms

Description	(±)-Carnitine chloride exists in two isomers, known as D and L. L-carnitine plays an essential role in the β-oxidation of fatty acids and also shows antioxidant, and anti-inflammatory activities.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Natural Products >> Others
In Vitro	The main role of L-carnitine is to shuttle long-chain fatty acids across the inner mitochondrial membrane. After L-carnitine and acyl-CoA become acyl-carnitine by activation of carnitine palmitoyl transferase (CPT)-I, the transported acyl-carnitine is changed into acyl-CoA by CPT-II in the mitochondria matrix. Palmitoyl-CoA-induced mitochondrial respiration is increased by L-carnitine treatment, and then is accelerated by the presence of ADP. This acceleration is induced by treatment with L-carnitine in a concentration-dependent manner, and is saturated at 5 mM L-carnitine[1]. Pretreatment with L-carnitine augments Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H2O2-treated HL7702 cells. L-carnitine protects HL7702 cells against H2O2-induced cell damage through Akt-mediated activation of Nrf2 signaling pathway[2].
In Vivo	L-carnitine is found to down-regulate the ubiquitin proteasome pathway and increase IGF-1 concentrations in animal models. L-carnitine administration for 2 weeks of hindlimb suspension alleviates the decrease in weight and fiber size in the soleus muscle. In addition, L-carnitine suppresses atrogin-1 mRNA expression, which has been reported to play a pivotal role in muscle atrophy[3]. Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-β1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR-γ[4].
Kinase Assay	Mitochondria (0.6 mg protein/mL) are incubated in 2.5 mM Hepes (pH7.4) containing 225 mM mannitol, 75 mM sucrose and 100 μM ethylene glycol tetraacetic acid (EGTA) with or without 5 mM L-carnitine at 25°C. To measure oxygen uptake, 10 min after inorganic phosphate (Pi) 4 mM are added, the mitochondria are treated with palmitoyl-CoA (50 μM) and then ADP is added (200 μM). Oligomycin (5 μM) and rotenone (10 μM) are added 3-4 min after the ADP treatment. HPG (0-10 mM), which can specifically inhibit carnitine palmitoyl transferase (CPT)-I activity in the mitochondria, is added in the Hepes medium before incubation of the mitochondria[1].
Animal Admin	Rats: After 1 week of acclimatization, rats are randomly assigned to a hindlimb suspension group, hindlimb suspension with L-carnitine administration group, and a pair-fed group. The L-carnitine group are administered a 1250 mg L-carnitine/kg dissolved in distilled water orally using a sonde. The body weight is measured every morning at 09:00 and L-carnitine solution is ingested every morning at 10:00. The experiment is conducted for 14 days[3].
References	[1]. Oyanagi E, et al. Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acidstress. Biochem Biophys Res Commun. 2011 Aug 19;412(1):61-7. [2]. Li J, et al. l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway. Can J Physiol Pharmacol. 2016 May;94(5):517-25. [3]. Jang J, et al. l-Carnitine supplement reduces skeletal muscle atrophy induced by prolonged hindlimb suspension in rats. Appl Physiol Nutr Metab. 2016 Dec;41(12):1240-1247. [4]. Zambrano S, et al. L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ. Am J Hypertens. 2014 Mar;27(3):460-70.

Melting Point	190-205ºC
Molecular Formula	C₇H₁₆ClNO₃
Molecular Weight	197.660
Exact Mass	197.081863
PSA	57.53000
Water Solubility	SOLUBLE

DL-Carnitine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP2979140

CHEMICAL NAME :: Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, chloride, (+-)-

CAS REGISTRY NUMBER :: 461-05-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H16-N-O3.Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	BP2979140
HS Code	2923900090

4-chloroacetoac...

CAS#:39082-00-3

Anilinium chloride

CAS#:142-04-1

DL-Carnitine hy...

CAS#:461-05-2

Literature: Lonza Ltd. Patent: US3969406 A1, 1976 ;

Precursor 2
CAS#:39082-00-3 4-chloroacetoac... CAS#:142-04-1 Anilinium chloride
DownStream 7
CAS#:5080-50-2 Acetyl-L-Carnit... CAS#:142674-34-8 3-(6,6,7,7,8,8,... CAS#:142674-38-2 3-(12,12,13,13,... CAS#:142674-35-9 3-tridecanoylox...
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HS Code	2923900090
Summary	2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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DL-Carnitine Hydrochloride

3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium chloride

3-Hydroxy-4-(trimethylammonio)butanoate hydrochloride

EINECS 207-309-1

UNII:F64264D63N

Vitamin BT Hydrochloride

Carnitine chloride

3-Hydroxy-4-(trimethylammonio)butyrate Hydrochloride

carnitine hydrochloride

MFCD00011904

3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt, hydrochloride (1:1)

1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride (1:1)

3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride

QV1YQ1K1&1&1 &&Anhydro HCl

(±)-Carnitine (chloride)

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: DL-Carnitine hydrochloride
Price: ￥108.0/25g ￥298.0/100g
Purity: 98.0%
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Contact: Liu jia

DC Chemicals Limited
China
Product Name: DL-Carnitine HCl
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DL-Carnitine hydrochloride
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: DL-Carnitine hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: carnitinamide chloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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DL-Carnitine hydrochloride

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