PDE4-IN-9

Modify Date: 2024-01-14 19:40:51

PDE4-IN-9 structure	Common Name	PDE4-IN-9
	CAS Number	2519450-32-7	Molecular Weight	328.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₂N₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PDE4-IN-9

PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].

Name	PDE4-IN-9

Description	PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Lin Y, et al. Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors. Eur J Med Chem. 2020 Dec 1;207:112795.

Molecular Formula	C₁₅H₁₂N₄O₃S
Molecular Weight	328.35

PDE4-IN-9

Use of PDE4-IN-9

Names

PDE4-IN-9 Biological Activity

Chemical & Physical Properties