PDE4-IN-11

Modify Date: 2024-04-06 15:23:32

PDE4-IN-11 structure	Common Name	PDE4-IN-11
	CAS Number	524734-30-3	Molecular Weight	350.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₉FN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PDE4-IN-11

PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research[1][2][3].

Name	PDE4-IN-11

Description	PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	PDE4
In Vitro	PDE4-IN-11 (example 12) exerts function in the monocrotaline reversal model of pulmonary hypertension[2]. PDE4-IN-11 (compound A1) displays antiinflammatory, anti-airways hyperreactivity and bronch odilator properties. PDE4-IN-11 also possesses immunosuppressive and TNFα secretion inhibitory activities[3].
References	[1]. Denholm A, et al. Preparation of naphthyridines as phosphodiesterase isoenzyme 4 (PDE4) inhibitors: World Intellectual Property Organization, WO2003039544[P]. 2003-05-15. [2]. McCarthy C, et al. Use of naphthyridine derivatives as medicaments for the treatment of pulmonary hypertension: World Intellectual Property Organization, WO2007088019[P]. 2007-08-09. [3]. Press NJ, et al. Organic compounds for treating pulmonary hypertension: World Intellectual Property Organization, WO2009013286. 2009-01-29.

Molecular Formula	C₂₁H₁₉FN₂O₂
Molecular Weight	350.39

PDE4-IN-11

Use of PDE4-IN-11

Names

PDE4-IN-11 Biological Activity

Chemical & Physical Properties