ZC0101

Modify Date: 2024-01-09 19:25:04

ZC0101 Structure
ZC0101 structure
Common Name ZC0101
CAS Number 2541604-52-6 Molecular Weight 293.32
Density N/A Boiling Point N/A
Molecular Formula C17H15N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ZC0101


ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1].

 Names

Name ZC0101

 ZC0101 Biological Activity

Description ZC0101 is a potent, orally active IDO1 and TrxR dual inhibitor with IC50 values of 0.084 μM and 7.98 μM, respectively. ZC0101 effectively induces apoptosis and ROS accumulation in cancer cells[1].
Related Catalog
Target

IDO1:0.084 μM (IC50)

TrxR:7.98 μM (IC50)

In Vivo ZC0101 (60 mg/kg; p.o.; once) effectively suppresses IDO1 activity in vivo[1].
References

[1]. Fan QZ, et al. Design, synthesis, and biological evaluation of a novel indoleamine 2,3-dioxigenase 1 (IDO1) and thioredoxin reductase (TrxR) dual inhibitor. Bioorg Chem. 2020 Dec;105:104401.

 Chemical & Physical Properties

Molecular Formula C17H15N3O2
Molecular Weight 293.32
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