4'-Hydroxy diclofenac D4

Modify Date: 2024-01-01 23:30:56

4'-Hydroxy diclofenac D4 structure	Common Name	4'-Hydroxy diclofenac D4
	CAS Number	254762-27-1	Molecular Weight	316.17300
	Density	1.54g/cm3	Boiling Point	432.709ºC at 760 mmHg
	Molecular Formula	C₁₄H₇Cl₂D₄NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	215.495ºC

Use of 4'-Hydroxy diclofenac D4

4'-Hydroxy diclofenac D4 is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

Name	2-[2,3,4,5-tetradeuterio-6-(2,6-dichloro-4-hydroxyanilino)phenyl]acetic acid

Description	4'-Hydroxy diclofenac D4 is the deuterium labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. [3]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16.

Density	1.54g/cm3
Boiling Point	432.709ºC at 760 mmHg
Molecular Formula	C₁₄H₇Cl₂D₄NO₃
Molecular Weight	316.17300
Flash Point	215.495ºC
Exact Mass	315.03700
PSA	69.56000
LogP	4.14270
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.69
Storage condition	-20°C

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4'-Hydroxy diclofenac D4
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 4'-Hydroxy diclofenac D4
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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