PKC-IN-4
Modify Date: 2025-08-26 18:30:24
PKC-IN-4 structure
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Common Name | PKC-IN-4 | ||
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| CAS Number | 2636771-29-2 | Molecular Weight | 379.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H25N5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PKC-IN-4PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature[1]. |
| Name | PKC-IN-4 |
|---|
| Description | PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature[1]. |
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| Related Catalog | |
| Target |
PKC:0.52 μM (IC50) |
| In Vitro | PKC-IN-4 (compound 7l) shows VEGF - induced endothelial permeability with an EC50 of 0.071 µM[1]. |
| In Vivo | PKC-IN-4 (10 mg/kg for i.v.; 20 mg/kg for p.o.) shows orally active with oral bioavailability of 81.7%[1]. Animal Model: Animal Model: CD-1 mice[1] Dosage: 10, 20 mg/kg Administration: 10 mg/kg for i.v.; 20 mg/kg for p.o. Result: Showed good PK parameters with oral bioavailability of 81.7%. |
| References |
| Molecular Formula | C21H25N5S |
|---|---|
| Molecular Weight | 379.52 |