PARP/EZH2-IN-1

Modify Date: 2024-01-24 08:36:27

Use of PARP/EZH2-IN-1

PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

Name	PARP/EZH2-IN-1

Description	PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Epigenetics >> Histone Methyltransferase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	PARP-1:6.87 nM (IC50) EZH2:36.51 nM (IC50)
References	[1]. Wang C, et al. Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. J Med Chem. 2021 Sep 9;64(17):12630-12650.

Molecular Formula	C₄₃H₄₁FN₈O₅
Molecular Weight	768.83

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