PARP/EZH2-IN-1

Modify Date: 2024-01-24 08:36:27

PARP/EZH2-IN-1 Structure
PARP/EZH2-IN-1 structure
Common Name PARP/EZH2-IN-1
CAS Number 2687273-52-3 Molecular Weight 768.83
Density N/A Boiling Point N/A
Molecular Formula C43H41FN8O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PARP/EZH2-IN-1


PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.

 Names

Name PARP/EZH2-IN-1

 PARP/EZH2-IN-1 Biological Activity

Description PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.
Related Catalog
Target

PARP-1:6.87 nM (IC50)

EZH2:36.51 nM (IC50)

References

[1]. Wang C, et al. Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA. J Med Chem. 2021 Sep 9;64(17):12630-12650.

 Chemical & Physical Properties

Molecular Formula C43H41FN8O5
Molecular Weight 768.83