CCG-273463

Modify Date: 2025-08-23 16:56:49

CCG-273463 Structure
CCG-273463 structure
 Common Name CCG-273463
CAS Number 2750413-99-9 Molecular Weight 521.41
Density N/A Boiling Point N/A
Molecular Formula C26H25BrN4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CCG-273463


CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 9 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].

 Names

Name CCG-273463

 CCG-273463 Biological Activity

Description CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 9 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].
Related Catalog
Target

IC50: 8.6 nM (GRK5), 12 μM (GRK2)[1].

In Vitro CCG-273463 (0.02-1 μM) potently and highly inhibits GRK5 (IC50: 9 nM), with inhibitory rate of 93% (GRK5) and 97% (GRK6) at 1 μM[1].
References

[1]. Rachel A Rowlands, et al. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem. 2021 Jan 14;64(1):566-585.

 Chemical & Physical Properties

Molecular Formula C26H25BrN4O3
Molecular Weight 521.41
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Chemsrc provides CCG-273463(CAS#:2750413-99-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of CCG-273463 are included as well.>> amp version: CCG-273463

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