mIDH1-IN-1
Modify Date: 2025-08-24 04:28:51
mIDH1-IN-1 structure
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Common Name | mIDH1-IN-1 | ||
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| CAS Number | 2757155-96-5 | Molecular Weight | 449.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H27N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of mIDH1-IN-1mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research[1]. |
| Name | mIDH1-IN-1 |
|---|
| Description | mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research[1]. |
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| Related Catalog | |
| Target |
IC50: 961.5 ± 25.3 nM (IDH1R132H); EC50: 208.6 ± 8.0 nM (2-HG)[1] |
| References |
| Molecular Formula | C25H27N3O5 |
|---|---|
| Molecular Weight | 449.50 |