HUP30

Modify Date: 2024-01-10 15:02:28

Use of HUP30

HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx[1].

Name	N-(6-nitro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
Synonym	More Synonyms

Description	HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	HUP30 抑制苯肾上腺素诱导的主动脉收缩，IC50 值为 3.9 μM[1]。 HUP30 (100 μM) 增加去氧肾上腺素刺激的主动脉中的 cGMP 水平[1]。 HUP30 对 25/30 mM K+ 收缩的大鼠主动脉环产生解痉作用，IC50 值为 7.5 μM[1] . HUP30 (3-100 μM) 抑制苯肾上腺素诱导的细胞外 Ca2+ 内流和 Ca2+ 动员[1]。 HUP30 (10-100 μM) 抑制单尾动脉肌细胞中的电流[1]。
References	[1]. Fusi F, et al. 2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations. Eur J Pharmacol. 2013 Aug 15;714(1-3):178-87.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

6-Nitrobenzo[d]...

CAS#:6285-57-0

chlorocarbonylc...

CAS#:2719-27-9

~67%

HUP30

CAS#:312747-21-0

Precursor 2
CAS#:6285-57-0 6-Nitrobenzo[d]... CAS#:2719-27-9 chlorocarbonylc...
DownStream 0

f0327-0054

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Price: ￥1050/10 mM * 1 mL in DMSO

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