HUP30

Modify Date: 2024-01-10 15:02:28

HUP30 Structure
HUP30 structure
Common Name HUP30
CAS Number 312747-21-0 Molecular Weight 305.35200
Density N/A Boiling Point N/A
Molecular Formula C14H15N3O3S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of HUP30


HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx[1].

 Names

Name N-(6-nitro-1,3-benzothiazol-2-yl)cyclohexanecarboxamide
Synonym More Synonyms

 HUP30 Biological Activity

Description HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx[1].
Related Catalog
In Vitro HUP30 抑制苯肾上腺素诱导的主动脉收缩,IC50 值为 3.9 μM[1]。 HUP30 (100 μM) 增加去氧肾上腺素刺激的主动脉中的 cGMP 水平[1]。 HUP30 对 25/30 mM K+ 收缩的大鼠主动脉环产生解痉作用,IC50 值为 7.5 μM[1] . HUP30 (3-100 μM) 抑制苯肾上腺素诱导的细胞外 Ca2+ 内流和 Ca2+ 动员[1]。 HUP30 (10-100 μM) 抑制单尾动脉肌细胞中的电流[1]。
References

[1]. Fusi F, et al. 2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations. Eur J Pharmacol. 2013 Aug 15;714(1-3):178-87.  

 Chemical & Physical Properties

Molecular Formula C14H15N3O3S
Molecular Weight 305.35200
Exact Mass 305.08300
PSA 119.54000
LogP 4.89600

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

f0327-0054
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