Mercaptoethylguanidine (MEG) (dihydrobromide)

Modify Date: 2024-01-08 17:14:55

Mercaptoethylguanidine (MEG) (dihydrobromide) Structure
Mercaptoethylguanidine (MEG) (dihydrobromide) structure
Common Name Mercaptoethylguanidine (MEG) (dihydrobromide)
CAS Number 32665-11-5 Molecular Weight 200.10100
Density N/A Boiling Point N/A
Molecular Formula C3H10BrN3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mercaptoethylguanidine (MEG) (dihydrobromide)


Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.

 Names

Name S-(2-Amino-ethyl)-isothiuroniumbromid-hydrobromid
Synonym More Synonyms

  Biological Activity

Description Mercaptoethylguanidine (MEG) dihydrobromide is selective inhibitor of the inducible nitric oxide synthase and peroxynitrite scavenger. Mercaptoethylguanidine (MEG) dihydrobromide has the potential for inflammatory bowel diseases research.
Related Catalog
In Vivo Mercaptoethylguanidine (MEG; 10 mg/kg i.v. b. i.d.) dihydrobromide significantly reduces the appearance of diarrhea and the loss of body weight in male rats with colitis[1]. Mercaptoethylguanidine (10 mg/kg/day; ip; for 5 days) dihydrobromide ameliorates oxidative stress parameters and antioxidant enzyme activities in forty-five Sprague-Dawley rats weighing 200 to 250 g with esophagus uninjured[2].
References

[1]. B Zingarelli, et al. Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther. 1998 Dec;287(3):1048-55.

[2]. Ahmet Guven, et al. Mercaptoethylguanidine attenuates caustic esophageal injury in rats: a role for scavenging of peroxynitrite. J Pediatr Surg. 2011 Sep;46(9):1746-52.

 Chemical & Physical Properties

Molecular Formula C3H10BrN3S
Molecular Weight 200.10100
Exact Mass 198.97800
PSA 100.70000
LogP 1.54830

 Synonyms

mercaptoethylguanidine (meg) dihydrobromide
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