sRANKL-IN-1

Modify Date: 2024-04-05 18:23:59

sRANKL-IN-1 Structure
sRANKL-IN-1 structure
Common Name sRANKL-IN-1
CAS Number 331968-10-6 Molecular Weight 418.42
Density N/A Boiling Point N/A
Molecular Formula C18H18N4O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of sRANKL-IN-1


sRANKL-IN-1 (compound S3) is a sRANKL (soluble RANKL) inhibitor. sRANKL-IN-1 shows a potent osteoclast inhibition effect with an IC50 value of 0.096 μM and a KD value of 34.80 μM. sRANKL-IN-1 can be used for the research of osteoporosis[1].

 Names

Name sRANKL-IN-1

 sRANKL-IN-1 Biological Activity

Description sRANKL-IN-1 (compound S3) is a sRANKL (soluble RANKL) inhibitor. sRANKL-IN-1 shows a potent osteoclast inhibition effect with an IC50 value of 0.096 μM and a KD value of 34.80 μM. sRANKL-IN-1 can be used for the research of osteoporosis[1].
Related Catalog
Target

IC50: 0.096 μM (osteoclast)[1]

In Vitro sRANKL-IN-1 (0-50 μM) shows potent inhibition to osteoclast[1]. Cell Viability Assay[1] Cell Line: Bone marrow cell line Concentration: 0-50 μM Incubation Time: Until osteoclasts formed Result: Inhibited osteoclasts formation with an IC50 value of 0.096 μM and a KD value of 34.80 μM.
References

[1]. Huang D, et al. Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nat Commun. 2022 Sep 12;13(1):5338.

 Chemical & Physical Properties

Molecular Formula C18H18N4O6S
Molecular Weight 418.42
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