JX-401

Modify Date: 2024-01-02 14:01:05

JX-401 structure	Common Name	JX-401
	CAS Number	349087-34-9	Molecular Weight	355.49400
	Density	1.17g/cm3	Boiling Point	537.3ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₅NO₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	278.8ºC

Use of JX-401

JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].

Name	(4-benzylpiperidin-1-yl)-(2-methoxy-4-methylsulfanylphenyl)methanone
Synonym	More Synonyms

Description	JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
References	[1]. Friedmann Y, et al. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol Pharmacol. 2006;70(4):1395-1405.

Density	1.17g/cm3
Boiling Point	537.3ºC at 760 mmHg
Molecular Formula	C₂₁H₂₅NO₂S
Molecular Weight	355.49400
Flash Point	278.8ºC
Exact Mass	355.16100
PSA	54.84000
LogP	4.44990
Index of Refraction	1.611