DNA2 inhibitor C5

Modify Date: 2024-01-10 16:59:20

DNA2 inhibitor C5 Structure
DNA2 inhibitor C5 structure
Common Name DNA2 inhibitor C5
CAS Number 35973-25-2 Molecular Weight 234.16500
Density 1.624g/cm3 Boiling Point 437.2ºC at 760mmHg
Molecular Formula C10H6N2O5 Melting Point N/A
MSDS N/A Flash Point 218.2ºC

 Use of DNA2 inhibitor C5


DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].

 Names

Name 8-nitro-4-oxo-1H-quinoline-3-carboxylic acid
Synonym More Synonyms

 DNA2 inhibitor C5 Biological Activity

Description DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].
Related Catalog
Target

IC50: 20 μM (DNA2 nuclease)[1]

References

[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.

 Chemical & Physical Properties

Density 1.624g/cm3
Boiling Point 437.2ºC at 760mmHg
Molecular Formula C10H6N2O5
Molecular Weight 234.16500
Flash Point 218.2ºC
Exact Mass 234.02800
PSA 116.24000
LogP 2.07000
Index of Refraction 1.674

 Safety Information

HS Code 2933499090

 Synthetic Route

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DNA2 inhibitor C5 Structure

DNA2 inhibitor C5

CAS#:35973-25-2

Literature: Pharmacia and Upjohn Company LLC Patent: EP1042295 B1, 2005 ; Location in patent: Page/Page column 59 ;

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DNA2 inhibitor C5 Structure

DNA2 inhibitor C5

CAS#:35973-25-2

Literature: Riegel et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 1264

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DNA2 inhibitor C5 Structure

DNA2 inhibitor C5

CAS#:35973-25-2

Literature: Riegel et al. Journal of the American Chemical Society, 1946 , vol. 68, p. 1264

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-hydroxy-8-nitroquinolone-3-carboxylic acid
4-hydroxy-8-nitroquinoline-3-carboxylic acid
4-Hydroxy-8-nitro-chinolin-3-carbonsaeure
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: NSC 15765
  • Price: $500.0/100mg $1000.0/250mg $2000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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