CDK4/6-IN-9

Modify Date: 2025-08-26 17:27:46

CDK4/6-IN-9 structure	Common Name	CDK4/6-IN-9
	CAS Number	2688098-02-2	Molecular Weight	418.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₃FN₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CDK4/6-IN-9

CDK4/6-IN-9 (compound 10) is a selective CDK4/6 inhibitor with an IC50 of 905 nM for CDK6/cyclin D1. CDK4/6-IN-9 has the potential for multiple myeloma (MM) research[1].

Name	CDK4/6-IN-9

Description	CDK4/6-IN-9 (compound 10) is a selective CDK4/6 inhibitor with an IC50 of 905 nM for CDK6/cyclin D1. CDK4/6-IN-9 has the potential for multiple myeloma (MM) research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK6/cyclinD1:905 nM (IC50) CDK4/cyclinD1
References	[1]. Kai Yuan, et al. Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma. Eur J Med Chem. 2022 Jan 15;228:114024.

Molecular Formula	C₂₂H₂₃FN₈
Molecular Weight	418.47
InChIKey	DIRJXVHFPSKLII-UHFFFAOYSA-N
SMILES	Cn1cc(-c2nc(Nc3ccc(CN4CCNCC4)cn3)ncc2F)c2cccnc21

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