2-Hydroxyestradiol
2-Hydroxyestradiol structure
|
Common Name | 2-Hydroxyestradiol | ||
|---|---|---|---|---|
| CAS Number | 362-05-0 | Molecular Weight | 288.38 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 481.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H24O3 | Melting Point | 96-104°C | |
| MSDS | Chinese USA | Flash Point | 227.6±23.3 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
|
A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.
J. Steroid Biochem. Mol. Biol. 118(1-2) , 70-6, (2010) A 17beta-estradiol (E(2)) is hydrolyzed to 2-hydroxy-E(2) (2-OHE(2)) and 4-hydroxy-E(2) (4-OHE(2)) via cytochrome P450 (CYP) 1A1 and 1B1, respectively. In estrogen target tissues including the mammary gland, ovaries, and uterus, CYP1B1 is highly expressed, an... |
|
|
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
J. Med. Chem. 48 , 5666-74, (2005) We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis... |
|
|
Norethisterone acetate alters coagulation gene expression in vitro in human cell culture.
Thromb. Res. 131(1) , 72-7, (2013) Both oestrogen and progestin and the route of administration have been implicated in cardiovascular and thromboembolic risk in post menopausal hormone users. Transdermal preparations have been reported as safer indicating that liver derived metabolites of oes... |
|
|
Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women.
J. Clin. Endocrinol. Metab. 99(12) , 4632-40, (2014) The gut microbiota may influence the risk of breast cancer through effects on endogenous estrogens.The objective of the study was to investigate whether urinary estrogens and estrogen metabolites are associated with the diversity and composition of the fecal ... |
|
|
Effects of alcohol consumption on plasma and urinary hormone concentrations in premenopausal women.
J. Natl. Cancer Inst. 85(9) , 722-7, (1993) Most epidemiologic studies of the relationship between alcohol consumption and breast cancer risk over the past decade have shown that persons who consume a moderate amount of alcohol are at 40%-100% greater risk of breast cancer than those who do not consume... |
|
|
Improved profiling of estrogen metabolites by orbitrap LC/MS.
Steroids 99 , 84-90, (2015) Estrogen metabolites are important biomarkers to evaluate cancer risks and metabolic diseases. Due to their low physiological levels, a sensitive and accurate method is required, especially for the quantitation of unconjugated forms of endogenous steroids and... |
|
|
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells.
J. Biol. Chem. 9th ed., 284 , 5774-5783, (2009) Alkalosis impairs the natriuretic response to diuretics, but the underlying mechanisms are unclear. The soluble adenylyl cyclase (sAC) is a chemosensor that mediates bicarbonate-dependent elevation of cAMP in intracellular microdomains. We hypothesized that s... |
|
|
Mitochondrial PKA mediates sperm motility.
Biochim. Biophys. Acta 1840(12) , 3404-12, (2014) Mitochondria are the major source of ATP to power sperm motility. Phosphorylation of mitochondrial proteins has been proposed as a major regulatory mechanism for mitochondrial bioenergetics.Sperm motility was measured by a computer-assisted analyzer, protein ... |
|
|
On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid.
Andrology , (2013) Oxidative stress is known to have a major impact on human sperm function and, as a result, there is a need to develop sensitive methods for measuring reactive oxygen species (ROS) generation by these cells. A variety of techniques have been developed for this... |
|
|
Nongenomic inhibition of coronary constriction by 17ß-estradiol, 2-hydroxyestradiol, and 2-methoxyestradiol.
Can. J. Physiol. Pharmacol. 88(2) , 147-52, (2010) The cardioprotective effects of 17beta-estradiol (E2) in women are hypothesized to be partially mediated by the E2 metabolites 2-hydroxyestradiol (2-HOE) and 2-methoxyestradiol (2-MeOH). Therefore, the purpose of our study was to determine the acute effects o... |