Kynuramine dihydrochloride

Modify Date: 2024-01-05 19:34:32

Kynuramine dihydrochloride structure	Common Name	Kynuramine dihydrochloride
	CAS Number	36681-58-0	Molecular Weight	237.13
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉H₁₄Cl₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Kynuramine dihydrochloride

Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].

Name	3-Amino-1-(2-aminophenyl)-1-propanone dihydrochloride
Synonym	More Synonyms

Description	Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Metabolic Disease
In Vitro	Kynuramine inhibits both presynaptic and postsynaptic α-adrenoceptors in vitro[2]. Kynuramine has been shown to act as a partial agonist on serotonin receptors in dog cerebral arteries[2]. Kynuramine (20 μg/mL) frequently causes a small contraction of the ileum but failed to alter the twitch response to cholinergic stimulation[2].
In Vivo	Kynuramine may serve a physiological role in the modulation of female sexual behavior[3]. Kynuramine increases heart rate and blood pressure in pithed rats[4]. Animal Model: Female rats[3]. Dosage: 0.064-8 μg. Administration: Intraventricular administration. Result: Produced facilitation of lordosis behavior.
References	[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.

1-Propanone, 3-amino-1-(2-aminophenyl)-, hydrochloride (1:2)

3-Amino-1-(2-aminophenyl)-1-propanone dihydrochloride

MFCD28384025

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Price: ￥1400/1 mg