Pamidronic acid

Modify Date: 2024-01-02 14:46:57

Pamidronic acid Structure
Pamidronic acid structure
 Common Name Pamidronic acid
CAS Number 40391-99-9 Molecular Weight 235.06900
Density 1.998 g/cm3 Boiling Point 658.7ºC at 760 mmHg
Molecular Formula C3H11NO7P2 Melting Point 226-228ºC
MSDS N/A Flash Point 352.2ºC

 Use of Pamidronic acid


Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.

 Names

Name Pamidronic acid
Synonym More Synonyms

 Pamidronic acid Biological Activity

Description Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases.
Related Catalog
Target

Wnt, β-catenin[1]

In Vitro Osteosarcoma cell viability decreases significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 μM, most consistently after 48 and 72 hours' exposure. In treated osteosarcoma cells, the lowest percentage cell viability is 34% (detected after 72 hours' exposure to 1000μM pamidronate)[1]. Pamidronate disodium inhibits Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reverses the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs[2].
In Vivo Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression[3].
Cell Assay Cell counts and cell viability assays are performed in cultures of osteosarcoma cells (POS, HMPOS, and COS31 cell lines) and fibroblasts after 24, 48, and 72 hours of incubation with pamidronate at concentrations of 0.001 to 1000 microM or with no drug (control treatment). Percentage viability is determined in cell samples for each concentration of pamidronate and each incubation time. A DNA fragmentation analysis is performed to assess bisphosphonate-induced apoptosis[1].
Animal Admin Rabbits: The rabbits are randomly divided into four groups. Sham-operated with vehicle treatment, OA induced by ACLT with vehicle treatment, OA-induced ACLT treated with short-term pamidronic acid treatment after ACLT, and ACLT treated with long-term PAM treatment. PAM is injected at the 4th week after ACLT in PAM-S and PAM-L groups, and followed by once monthly ear vein injections at a dosage of 3 mg/kg body weight. In the other groups, only saline infusions of equal volumes are administered. 10 animals are humanely sacrificed at both 2 and 10 weeks after pamidronic acid treatment. In the ACLT and Sham groups, five animals are sacrificed at 2, 4, 6, and 14 weeks after model establishment[3].
References

[1]. Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66(5):885-91.

[2]. Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22.

[3]. Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370.

 Chemical & Physical Properties

Density 1.998 g/cm3
Boiling Point 658.7ºC at 760 mmHg
Melting Point 226-228ºC
Molecular Formula C3H11NO7P2
Molecular Weight 235.06900
Flash Point 352.2ºC
Exact Mass 235.00100
PSA 180.93000
Index of Refraction 1.611
Storage condition 2-8℃

 Precursor & DownStream

Precursor  1

DownStream  1

 Synonyms

Pamidronic Acid See P172500
Pamidronic Acid
EINECS 254-905-2
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