Ethyl ferulate

Modify Date: 2024-01-02 22:13:07

Ethyl ferulate Structure
Ethyl ferulate structure
Common Name Ethyl ferulate
CAS Number 4046-02-0 Molecular Weight 222.24
Density 1.2±0.1 g/cm3 Boiling Point 382.3±0.0 °C at 760 mmHg
Molecular Formula C12H14O4 Melting Point 63-65 °C(lit.)
MSDS Chinese USA Flash Point 132.5±17.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Ethyl ferulate


Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from giant fennel (F. communis), induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity[2].

 Names

Name Ethyl 4'-hydroxy-3'-methoxycinnamate
Synonym More Synonyms

 Ethyl ferulate Biological Activity

Description Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from giant fennel (F. communis), induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity[2].
Related Catalog
References

[1]. Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6(5):811-8.

[2]. Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92(4):749-58.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 382.3±0.0 °C at 760 mmHg
Melting Point 63-65 °C(lit.)
Molecular Formula C12H14O4
Molecular Weight 222.24
Flash Point 132.5±17.2 °C
Exact Mass 222.089203
PSA 55.76000
LogP 1.94
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.566

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918990090

 Synthetic Route

~93%

Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Literature: Molecules, , vol. 14, # 6 p. 2118 - 2126

~96%

Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Literature: Tetrahedron, , vol. 59, # 7 p. 1049 - 1054

~82%

Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Literature: Organic Letters, , vol. 14, # 15 p. 3902 - 3905

~92%

Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Literature: Journal of the American Chemical Society, , vol. 134, # 46 p. 18889 - 18891

~%

Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Literature: Tetrahedron, , vol. 57, # 2 p. 365 - 370

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Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Literature: Liebigs Annalen der Chemie, , # 12 p. 2135 - 2140

~%

Ethyl ferulate Structure

Ethyl ferulate

CAS#:4046-02-0

Literature: Chemische Berichte, , vol. 85, p. 1181,1188

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles26

More Articles
Soluble and cell wall-bound phenolic acids and ferulic acid dehydrodimers in rye flour and five bread model systems: insight into mechanisms of improved availability.

J. Sci. Food Agric. 95(5) , 1103-15, (2015)

The bread-making process influences bread components, including phenolics that significantly contribute to its antioxidant properties. Five bread model systems made from different rye cultivars were i...

Hydroxycinnamic acid ethyl esters as precursors to ethylphenols in wine.

J. Agric. Food Chem. 60(9) , 2293-8, (2012)

A method for determining ethyl coumarate and ethyl ferulate in wine using GC-MS with deuterium-labeled analogues has been developed and used to measure the evolution of these two esters during the pro...

Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells.

Biosci. Biotechnol. Biochem. 60(2) , 316-8, (1996)

Cytotoxicity and DNA single-strand breaks caused by H2O2 were assessed by a colony formation assay and a DNA precipitation assay, respectively, with Chinese hamster V79 cells. In both assays, caffeic ...

 Synonyms

ethyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
MFCD00009190
4-Hydroxy-3-methoxycinnamic Acid Ethyl Ester
Ferulic acid ethyl ester
Ethyl 4-Hydroxy-3-MethoxycinnaMate
2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, ethyl ester
EINECS 223-745-5
Ethyl Ferulate
Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate
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