CYCLOARTENOL

Modify Date: 2025-08-21 16:40:02

CYCLOARTENOL Structure
CYCLOARTENOL structure
 Common Name CYCLOARTENOL
CAS Number 469-38-5 Molecular Weight 426.71700
Density 1.01 g/cm3 Boiling Point 505.5ºC at 760 mmHg
Molecular Formula C30H50O Melting Point 115-117ºC
MSDS N/A Flash Point 221.9ºC

 Use of CYCLOARTENOL


Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].

 Names

Name cycloartenol
Synonym More Synonyms

 CYCLOARTENOL Biological Activity

Description Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].
Related Catalog
In Vitro Cycloartenol inhibits the proliferation and the colony formation potential of the glioma U87 cells in a concentration-dependent manner. The antiproliferative effects are found to be due to induction of Sub-G1 cell cycle arrest and triggering of apoptosis. Cycloartenol also causes significant alteration in the expression of Bax and Bcl-2[2].
References

[1]. Niu H, et al. Cycloartenol exerts anti-proliferative effects on Glioma U87 cells via induction of cell cycle arrest and p38 MAPK-mediated apoptosis. J BUON. 2018 Nov-Dec;23(6):1840-1845.

[2]. Zhang ZL, et al. [Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity]. Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):433-437.

 Chemical & Physical Properties

Density 1.01 g/cm3
Boiling Point 505.5ºC at 760 mmHg
Melting Point 115-117ºC
Molecular Formula C30H50O
Molecular Weight 426.71700
Flash Point 221.9ºC
Exact Mass 426.38600
PSA 20.23000
LogP 8.16890
Vapour Pressure 2.47E-12mmHg at 25°C
Index of Refraction 1.538
InChIKey ONQRKEUAIJMULO-SBAQNCMESA-N
SMILES CC(C)=CCCC(C)C1CCC2(C)C3CCC4C(C)(C)C(O)CCC45CC35CCC12C

 Safety Information

Hazard Codes Xi: Irritant;
Safety Phrases 22-24/25

 Synthetic Route

Methanol structure

Methanol

CAS#:67-56-1

Cycloartenyl ferulate structure

Cycloartenyl fe...

CAS#:21238-33-5

~%

24-methylenecycloartanol structure

24-methylenecyc...

CAS#:1449-09-8

CYCLOARTENOL Structure

CYCLOARTENOL

CAS#:469-38-5

Literature: MORINAGA MILK INDUSTRY CO., LTD. Patent: EP1882472 A1, 2008 ; Location in patent: Page/Page column 14 ;
Cycloartenyl ferulate structure

Cycloartenyl fe...

CAS#:21238-33-5

~93%

CYCLOARTENOL Structure

CYCLOARTENOL

CAS#:469-38-5

Literature: Yoshida, Kumi; Hirose, Yoshihiko; Imai, Yutaka; Kondo, Tadao Agricultural and Biological Chemistry, 1989 , vol. 53, # 7 p. 1901 - 1912
2,3-Oxidosqualene structure

2,3-Oxidosqualene

CAS#:14050-42-1

~%

Parkeol structure

Parkeol

CAS#:514-45-4

CYCLOARTENOL Structure

CYCLOARTENOL

CAS#:469-38-5

Lanosterin structure

Lanosterin

CAS#:79-63-0

Literature: Hart, Elizabeth A.; Hua, Ling; Darr, Lisa B.; Wilson, William K.; Pang, Jihai; Matsuda, Seiichi P. T. Journal of the American Chemical Society, 1999 , vol. 121, # 42 p. 9887 - 9888
3(S)-Oxidosqualene structure

3(S)-Oxidosqualene

CAS#:54910-48-4

~%

Parkeol structure

Parkeol

CAS#:514-45-4

CYCLOARTENOL Structure

CYCLOARTENOL

CAS#:469-38-5

Lanosterin structure

Lanosterin

CAS#:79-63-0

Literature: Lodeiro, Silvia; Schulz-Gasch, Tanja; Matsuda, Seiichi P. T. Journal of the American Chemical Society, 2005 , vol. 127, # 41 p. 14132 - 14133
Cycloartenol acetate structure

Cycloartenol acetate

CAS#:1259-10-5

~%

CYCLOARTENOL Structure

CYCLOARTENOL

CAS#:469-38-5

Literature: Seo, Shujiro; Uomori, Atsuko; Yoshimura, Yohko; Takeda, Ken'ichi; Seto, Haruo; et.al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2407 - 2414
2,3-Oxidosqualene structure

2,3-Oxidosqualene

CAS#:14050-42-1

~%

CYCLOARTENOL Structure

CYCLOARTENOL

CAS#:469-38-5

Literature: Matsuda; Darr; Hart; Herrera; McCann; Meyer; Pang; Schepmann Organic letters, 2000 , vol. 2, # 15 p. 2261 - 2263
Arundinol structure

Arundinol

CAS#:136891-87-7

~%

CYCLOARTENOL Structure

CYCLOARTENOL

CAS#:469-38-5

Literature: Majumder; Ghosal Journal of the Indian Chemical Society, 1991 , vol. 68, # 2 p. 88 - 91

 CYCLOARTENOLBioassay

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Name: Activity of soybean recombinant SMT1
Source: ChEMBL
Target: N/A
External Id: CHEMBL928541
Name: Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells a...
Source: ChEMBL
Target: Human gammaherpesvirus 4
External Id: CHEMBL905095
Name: Cell viability of Raji cells at 320 nM
Source: ChEMBL
Target: Raji
External Id: CHEMBL905096
Name: Scavenging activity against NO generation in human Chang liver cells assessed as inhi...
Source: ChEMBL
Target: N/A
External Id: CHEMBL905097
Name: Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV...
Source: ChEMBL
Target: Human gammaherpesvirus 4
External Id: CHEMBL905091
Name: Activity of soybean sterol C24-methyltransferase 1
Source: ChEMBL
Target: N/A
External Id: CHEMBL991002
Name: Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV...
Source: ChEMBL
Target: Human gammaherpesvirus 4
External Id: CHEMBL905092
Name: Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV...
Source: ChEMBL
Target: Human gammaherpesvirus 4
External Id: CHEMBL905093
Name: Inhibition of TPA-induced Epstein-Barr virus early antigen activation assessed as EBV...
Source: ChEMBL
Target: Human gammaherpesvirus 4
External Id: CHEMBL905094
Name: Effect on Phytophthora cactorum growth assessed as colony diameter at 10 mg/L after 6...
Source: ChEMBL
Target: Phytophthora cactorum
External Id: CHEMBL1028476
Total 10, Current Page 1 of 1
1

 Synonyms

CYCLOARTENOL
9,19-Cyclolanost-24-en-3-ol
9,19-CYCLO-9BETA-LANOST-24-EN-3BETA-OL
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