chelidonine

Modify Date: 2024-01-02 16:10:03

chelidonine structure	Common Name	chelidonine
	CAS Number	476-32-4	Molecular Weight	353.369
	Density	1.4±0.1 g/cm3	Boiling Point	507.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₉NO₅	Melting Point	135-140ºC
	MSDS	N/A	Flash Point	260.7±30.1 °C

Use of chelidonine

Chelidonine is an isoquinoline alkaloid isolated from Chelidonium majus L., causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, with anticancer and antiviral activity[1].

Name	chelidonine
Synonym	More Synonyms

Description	Chelidonine is an isoquinoline alkaloid isolated from Chelidonium majus L., causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, with anticancer and antiviral activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection
References	[1]. Lee YK, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019 May 26;2019:6318179.

Density	1.4±0.1 g/cm3
Boiling Point	507.4±50.0 °C at 760 mmHg
Melting Point	135-140ºC
Molecular Formula	C₂₀H₁₉NO₅
Molecular Weight	353.369
Flash Point	260.7±30.1 °C
Exact Mass	353.126312
PSA	60.39000
LogP	2.75
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.667

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL9450000

CHEMICAL NAME :: Chelidonine

CAS REGISTRY NUMBER :: 476-32-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C20-H19-N-O5

MOLECULAR WEIGHT :: 353.40

WISWESSER LINE NOTATION :: T H5 F6 E6 B665 DN IO KO VO A&O JH WH&&TT&&J D1 PQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965- Volume(issue)/page/year: 25,209,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,135,1960

Hazard Codes	Xn
Risk Phrases	R20/21/22;R25
Safety Phrases	S20-S36/37-S45
RIDADR	UN 2811
RTECS	FL9450000
HS Code	2933990090

(+)-11,12-isopr...

CAS#:1337985-43-9

chelidonine

CAS#:476-32-4

Literature: Ito, Miki; Konno, Fujiko; Kumamoto, Takuya; Suzuki, Noriyuki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ishikawa, Tsutomu Tetrahedron, 2011 , vol. 67, # 41 p. 8041 - 8049

benzyl (5bR,5cR...

CAS#:1032645-05-8

~88%

chelidonine

CAS#:476-32-4

Literature: Fleming, Matthew J.; McManus, Helen A.; Rudolph, Alena; Chan, Walter H.; Ruiz, Jeremy; Dockendorff, Chris; Lautens, Mark Chemistry - A European Journal, 2008 , vol. 14, # 7 p. 2112 - 2124

N/A

CAS#:1337985-26-8

chelidonine

CAS#:476-32-4

Literature: Ito, Miki; Konno, Fujiko; Kumamoto, Takuya; Suzuki, Noriyuki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ishikawa, Tsutomu Tetrahedron, 2011 , vol. 67, # 41 p. 8041 - 8049

(-)-5-methyl-2,...

CAS#:1337985-30-4

chelidonine

CAS#:476-32-4

Literature: Ito, Miki; Konno, Fujiko; Kumamoto, Takuya; Suzuki, Noriyuki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ishikawa, Tsutomu Tetrahedron, 2011 , vol. 67, # 41 p. 8041 - 8049

(-)-12-(3-chlor...

CAS#:1337985-33-7

chelidonine

CAS#:476-32-4

Literature: Ito, Miki; Konno, Fujiko; Kumamoto, Takuya; Suzuki, Noriyuki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ishikawa, Tsutomu Tetrahedron, 2011 , vol. 67, # 41 p. 8041 - 8049

(-)-10b,11,12-t...

CAS#:1337985-40-6

chelidonine

CAS#:476-32-4

Literature: Ito, Miki; Konno, Fujiko; Kumamoto, Takuya; Suzuki, Noriyuki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ishikawa, Tsutomu Tetrahedron, 2011 , vol. 67, # 41 p. 8041 - 8049

N/A

CAS#:1337985-42-8

chelidonine

CAS#:476-32-4

Literature: Ito, Miki; Konno, Fujiko; Kumamoto, Takuya; Suzuki, Noriyuki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ishikawa, Tsutomu Tetrahedron, 2011 , vol. 67, # 41 p. 8041 - 8049

N/A

CAS#:1337985-20-2

chelidonine

CAS#:476-32-4

Literature: Ito, Miki; Konno, Fujiko; Kumamoto, Takuya; Suzuki, Noriyuki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ishikawa, Tsutomu Tetrahedron, 2011 , vol. 67, # 41 p. 8041 - 8049

Ethanol

CAS#:64-17-5

(+)-Didehydroch...

CAS#:24181-71-3

chelidonine

CAS#:476-32-4

Literature: Benn; Mitchell Canadian Journal of Chemistry, 1969 , vol. 47, p. 3701

Precursor 5
CAS#:1032645-05-8 benzyl (5bR,5cR... CAS#:1337985-33-7 (-)-12-(3-chlor... CAS#:1337985-40-6 (-)-10b,11,12-t... CAS#:64-17-5 Ethanol
CAS#:24181-71-3 (+)-Didehydroch...
DownStream 2
CAS#:3606-45-9 dihydrosanguinarine CAS#:522-30-5 Norsanguinarine

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(5bR,6S,12bS)-13-Methyl-5b,6,7,12b,13,14-hexahydro[1,3]dioxolo[4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol

EINECS 207-504-1

Chelidonine

Khelidonin

(5bR,6S,12bS)-13-Methyl-5b,6,7,12b,13,14-hexahydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol

MFCD00069660

[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-13-methyl-, (5bR,6S,12bS)-

Chelidonin

(5bR,6S,12bS)-13-Méthyl-5b,6,7,12b,13,14-hexahydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phénanthridin-6-ol

[5bR-(5ba,6b,12b4a)]-5b,6,7,12b,13,14-hexahydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-di oxolo[4,5-i]phenanthridin-6-ol

Diphylline

Helidonine

Stylophorin

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: chelidonine
Price: ￥1178.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Chelidonine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Chelidonine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Chelidonine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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