Methyl gallate

Modify Date: 2025-08-20 19:28:33

Methyl gallate structure	Common Name	Methyl gallate
	CAS Number	99-24-1	Molecular Weight	184.146
	Density	1.5±0.1 g/cm3	Boiling Point	450.1±40.0 °C at 760 mmHg
	Molecular Formula	C₈H₈O₅	Melting Point	201-204 °C
	MSDS	Chinese USA	Flash Point	190.8±20.8 °C
	Symbol	GHS07	Signal Word	Warning

Use of Methyl gallate

Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity.

Name	Methyl Gallate
Synonym	More Synonyms

Description	Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Cardiovascular Disease Research Areas >> Cancer Research Areas >> Infection Natural Products >> Phenols
Target	Bacterial[1]
In Vitro	The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL)[1]. Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period[2]. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate[3].
Cell Assay	KB cells, a human mouth epithelial cell line, are treated with Methyl gallate (1-8 mg/mL) for 24 h. Cytotoxicity of Methyl gallate is assessed by a modified MTT assay[1].
References	[1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50. [2]. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50. [3]. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010 Dec 1;185(11):6698-705.

Density	1.5±0.1 g/cm3
Boiling Point	450.1±40.0 °C at 760 mmHg
Melting Point	201-204 °C
Molecular Formula	C₈H₈O₅
Molecular Weight	184.146
Flash Point	190.8±20.8 °C
Exact Mass	184.037170
PSA	86.99000
LogP	1.54
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.631
Storage condition	2-8°C
Water Solubility	SOLUBLE IN HOT WATER

Methyl gallate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LW8000000

CHEMICAL NAME :: Gallic acid, methyl ester

CAS REGISTRY NUMBER :: 99-24-1

BEILSTEIN REFERENCE NO. :: 2113180

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-O5

MOLECULAR WEIGHT :: 184.16

WISWESSER LINE NOTATION :: QVR CQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 784 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H317-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R22;R36/37/38;R43
Safety Phrases	S26-S36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LW8000000
HS Code	2918290000

Precursor 9
CAS#:67-56-1 Methanol CAS#:149-91-7 Gallic acid CAS#:77-78-1 Dimethyl sulfate CAS#:66656-94-8 methyl 6-O-gall...
CAS#:75-36-5 Acetyl chloride CAS#:74-88-4 methyl iodide CAS#:35388-10-4 3,4,5-trihydrox... CAS#:7647-01-0 Hydrochloric acid
CAS#:7664-93-9 Sulfuric acid
DownStream 10
CAS#:111394-44-6 (Z)-2-Methoxy-5... CAS#:3934-84-7 3,4-Dihydroxy-5... CAS#:3934-86-9 Methyl 3,4-dihy... CAS#:41303-74-6 N-Desmethyl Gal...
CAS#:146300-69-8 7-hydroxy-2,2-d... CAS#:143259-87-4 methyl 3,4-dihy... CAS#:1486-47-1 3,4,5-tris(phen... CAS#:142531-43-9 methyl 7-phenyl...
CAS#:477-90-7 Bergenin CAS#:188685-16-7 methyl 3,4,5-tr...

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

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J. Food Sci. Technol. 51(8) , 1453-62, (2014)

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Methyl gallate

MFCD00002194

3,4,5-Trihydroxybenzoic acid methyl ester

Benzoic acid, 3,4,5-trihydroxy-, methyl ester

Methyl 3,4,5-trihydroxybenzoate

EINECS 202-741-7

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China
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China
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China
Product Name: Methyl gallate
Price: ￥Inquiry/25kg
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Delivery: Inquiry
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Methyl gallate

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