Methyl gallate

Modify Date: 2026-07-01 19:39:25

Methyl gallate Structure
Methyl gallate structure
 Common Name Methyl gallate
CAS Number 99-24-1 Molecular Weight 184.146
Density 1.5±0.1 g/cm3 Boiling Point 450.1±40.0 °C at 760 mmHg
Molecular Formula C8H8O5 Melting Point 201-204 °C
MSDS Chinese USA Flash Point 190.8±20.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Methyl gallate


Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity.

Summary: Methyl Gallate, Chinese name Meisishi suace, CAS number 99-24-1, molecular formula C8H8O5, molecular weight 184.146. Appearance: white to slightly brownish crystalline powder, melting point 201-204°C, boiling point 450.1±40.0°C, density 1.5±0.1g/cm3. Mainly used as intermediate for biphenyl-bisphenol and other drugs, also a rubber anti-aging agent. For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Methyl Gallate
Synonym More Synonyms

 Methyl gallate Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity.
Related Catalog
Target

Bacterial[1]

In Vitro The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL)[1]. Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period[2]. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate[3].
Cell Assay KB cells, a human mouth epithelial cell line, are treated with Methyl gallate (1-8 mg/mL) for 24 h. Cytotoxicity of Methyl gallate is assessed by a modified MTT assay[1].
References

[1]. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50.

[2]. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50.

[3]. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010 Dec 1;185(11):6698-705.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.5±0.1 g/cm3
Boiling Point 450.1±40.0 °C at 760 mmHg
Melting Point 201-204 °C
Molecular Formula C8H8O5
Molecular Weight 184.146
Flash Point 190.8±20.8 °C
Exact Mass 184.037170
PSA 86.99000
LogP 1.54
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.631
InChIKey FBSFWRHWHYMIOG-UHFFFAOYSA-N
SMILES COC(=O)c1cc(O)c(O)c(O)c1
Storage condition 2-8°C
Water Solubility SOLUBLE IN HOT WATER

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LW8000000
CHEMICAL NAME :
Gallic acid, methyl ester
CAS REGISTRY NUMBER :
99-24-1
BEILSTEIN REFERENCE NO. :
2113180
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H8-O5
MOLECULAR WEIGHT :
184.16
WISWESSER LINE NOTATION :
QVR CQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
784 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
470 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),286,1982

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H317-H319-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R22;R36/37/38;R43
Safety Phrases S26-S36/37
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LW8000000
HS Code 2918290000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

 Articles40

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

An Antioxidant Extract of the Insectivorous Plant Drosera burmannii Vahl. Alleviates Iron-Induced Oxidative Stress and Hepatic Injury in Mice.

PLoS ONE 10 , e0128221, (2015)

Free iron typically leads to the formation of excess free radicals, and additional iron deposition in the liver contributes to the oxidative pathologic processes of liver disease. Many pharmacological...

Characterization and storage stability of the extract of Thai mango (Mangifera indica Linn. Cultivar Chok-Anan) seed kernels.

J. Food Sci. Technol. 51(8) , 1453-62, (2014)

Qualitative analysis of hydrolysable extract from mango (Mangifera indica Linn. cultivar Chok-Anan) seed kernel was performed by means of reversed phase high-performance liquid chromatography coupled ...

 Methyl gallateBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Antifungal activity against Saccharomyces cerevisiae ATCC 7754 after 48 hr by microdi...
Source: ChEMBL
Target: Saccharomyces cerevisiae
External Id: CHEMBL3083012
Name: Inhibition of HIV1 recombinant integrase expressed in Escherichia coli
Source: ChEMBL
Target: Integrase
External Id: CHEMBL1026710
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity
Name: Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: GDH-TPI_INH_ABS_1536_1X%INH CSRUN
Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Methyl gallate
MFCD00002194
3,4,5-Trihydroxybenzoic acid methyl ester
Benzoic acid, 3,4,5-trihydroxy-, methyl ester
Methyl 3,4,5-trihydroxybenzoate
EINECS 202-741-7

 Methyl gallate | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular formula of Methyl Gallate?
A: Molecular formula of Methyl Gallate is C8H8O5.
Q: What are the downstream products of Methyl Gallate?
A: Related downstream products(CAS) of Methyl Gallate: 111394-44-6;3934-84-7;3934-86-9;41303-74-6;146300-69-8;143259-87-4;1486-47-1;142531-43-9;477-90-7;188685-16-7.
Q: What is the boiling point of Methyl Gallate?
A: Boiling point of Methyl Gallate is 450.1±40.0 °C at 760 mmHg.
Q: What is the molecular weight of Methyl Gallate?
A: Molecular weight of Methyl Gallate is 184.146.
Q: What are the upstream materials of Methyl Gallate?
A: Related upstream materials(CAS) of Methyl Gallate: 67-56-1;149-91-7;77-78-1;66656-94-8;75-36-5;74-88-4;35388-10-4;7647-01-0;7664-93-9.
Q: What English synonyms does Methyl Gallate have?
A: English synonyms of Methyl Gallate: Methyl gallate, MFCD00002194, 3,4,5-Trihydroxybenzoic acid methyl ester, Benzoic acid, 3,4,5-trihydroxy-, methyl ester, Methyl 3,4,5-trihydroxybenzoate, EINECS 202-741-7.
Q: What is the polar surface area (PSA) of Methyl Gallate?
A: Polar surface area (PSA) of Methyl Gallate is 86.99000.
Q: What is the SMILES notation of Methyl Gallate?
A: SMILES notation of Methyl Gallate is COC(=O)c1cc(O)c(O)c(O)c1.
Q: What are the storage conditions for Methyl Gallate?
A: Storage conditions for Methyl Gallate: 2-8°C.
Q: How is the water solubility of Methyl Gallate?
A: Water solubility of Methyl Gallate: SOLUBLE IN HOT WATER.

 Methyl gallatefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides Methyl gallate(CAS#:99-24-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Methyl gallate are included as well.>> amp version: Methyl gallate

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