AT2 receptor agonist C21
Modify Date: 2024-01-09 18:30:07
AT2 receptor agonist C21 structure
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Common Name | AT2 receptor agonist C21 | ||
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| CAS Number | 477775-14-7 | Molecular Weight | 475.624 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H29N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AT2 receptor agonist C21AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively[1]. |
| Name | compound 21 [PMID: 22802221] |
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| Synonym | More Synonyms |
| Description | AT2 receptor agonist C21 is a druglike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively[1]. |
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| Related Catalog | |
| Target |
Ki: 0.4 nM (AT2) and >10 µM (AT1)[1] |
| In Vivo | AT2 receptor agonist C21, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H29N3O4S2 |
| Molecular Weight | 475.624 |
| Exact Mass | 475.159943 |
| LogP | 4.93 |
| Index of Refraction | 1.615 |
| Butyl ({3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-isobutyl-2-thienyl}sulfonyl)carbamate |
| butyl ({3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl}sulfonyl)carbamate |
| compound 21 [PMID: 22802221] |
| Carbamic acid, N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester |
| N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamide |