IRAK-1-4 Inhibitor I
Modify Date: 2024-01-04 11:13:18
IRAK-1-4 Inhibitor I structure
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Common Name | IRAK-1-4 Inhibitor I | ||
|---|---|---|---|---|
| CAS Number | 509093-47-4 | Molecular Weight | 395.41200 | |
| Density | 1.4 | Boiling Point | N/A | |
| Molecular Formula | C20H21N5O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively. |
| Name | N-[1-(2-morpholin-4-ylethyl)benzimidazol-2-yl]-3-nitrobenzamide |
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| Synonym | More Synonyms |
| Description | IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively. |
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| Related Catalog | |
| Target |
IC50: 0.2 μM (IRAK-4), 0.3 μM (IRAK-1)[1] |
| In Vitro | IRAK-1-4 Inhibitor I has IC50 greater than the highest concentration tested (10 μM) against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC. Additionally, IRAK-1-4 Inhibitor I does not show any signs of cytotoxicity in a 72 h proliferation assay in HeLa cells (ED50>30 μM). Significant inhibition of IRAK-1 is observed with IRAK-1-4 Inhibitor I (IRAK-1 IC50=0.3 μM)[1]. IRAK-1/4 inhibitor eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8. IRAK-1/4 mediates LPS-induced IL-8 activation and functions upstream of Bcl10. The LPS-induced increase in Bcl10 declines by 73% (from 5.18±0.22 to 2.36±0.08 ng/mL), and the IL-8 response decline by 60% (from 2.64±0.31 to 1.14±0.08 ng/mL)[2]. |
| Cell Assay | NCM460 cells, grown in 24-well plates, are incubated with 50 μM IRAK-1/4 inhibitor for 2 h. After 2 h, the media are changed, and new media with or without LPS (10 ng/mL) added. Treatment is terminated at 6 h, and spent media and cells are collected for IL-8 and other assays[2]. |
| References |
| Density | 1.4 |
|---|---|
| Molecular Formula | C20H21N5O4 |
| Molecular Weight | 395.41200 |
| Exact Mass | 395.15900 |
| PSA | 108.70000 |
| LogP | 3.37410 |
| Storage condition | 2-8℃ |
| Risk Phrases | 25-36/37/38 |
|---|---|
| Safety Phrases | 26-36/37-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| Benzamide,N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro |
| IRAK-1/4 Inhibitor |
| N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole |
| Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor |
| IRAK-1/4 Inhibitor I |
| IRAK-1-4 Inhibitor I |