12-Hydroxyabieta-8(14),9(11),12-trien-7-one
12-Hydroxyabieta-8(14),9(11),12-trien-7-one structure
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Common Name | 12-Hydroxyabieta-8(14),9(11),12-trien-7-one | ||
|---|---|---|---|---|
| CAS Number | 511-05-7 | Molecular Weight | 300.435 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 437.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H28O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 186.4±21.3 °C | |
Use of 12-Hydroxyabieta-8(14),9(11),12-trien-7-oneSugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | sugiol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1]. |
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| Related Catalog | |
| Target |
ERK1 ERK2 p38 MAPK JNK1 JNK2 IL-1β |
| In Vitro | Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。 Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。 Western Blot Analysis[1] Cell Line: J774A.1 macrophages cells stimulated with LPS Concentration: 5 μM, 10 μM, 20 μM, and 30 μM Incubation Time: 30 min Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.2±45.0 °C at 760 mmHg |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.435 |
| Flash Point | 186.4±21.3 °C |
| Exact Mass | 300.208923 |
| PSA | 37.30000 |
| LogP | 6.77 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.539 |
| InChIKey | IPEHJNRNYPOFII-AZUAARDMSA-N |
| SMILES | CC(C)c1cc2c(cc1O)C1(C)CCCC(C)(C)C1CC2=O |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 12-Hydroxyabieta-8,11,13-triene-7-one |
| 7-oxo-8,11,13-abietatrien-12-ol |
| 12-Hydroxy-abieta-8,11,13-trien-7-on |
| 12-hydroxy-abieta-8,11,13-trien-7-one |
| 12-Hydroxyabieta-8(14),9(11),12-trien-7-one |
| 10-Deoxoxanthoperol |
| 12-hidroxyabieta-8,11,13-trien-7-one |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of sugiol? |
| A: Molecular weight of sugiol is 300.435. |
| Q: What is the molecular formula of sugiol? |
| A: Molecular formula of sugiol is C20H28O2. |
| Q: What is the LogP of sugiol? |
| A: LogP of sugiol is 6.77. |
| Q: What are the uses of sugiol? |
| A: Main uses of sugiol: Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1]. |
| Q: What is the polar surface area (PSA) of sugiol? |
| A: Polar surface area (PSA) of sugiol is 37.30000. |
| Q: What English synonyms does sugiol have? |
| A: English synonyms of sugiol: 12-Hydroxyabieta-8,11,13-triene-7-one, 7-oxo-8,11,13-abietatrien-12-ol, 12-Hydroxy-abieta-8,11,13-trien-7-on, 12-hydroxy-abieta-8,11,13-trien-7-one, 12-Hydroxyabieta-8(14),9(11),12-trien-7-one, 10-Deoxoxanthoperol, 12-hidroxyabieta-8,11,13-trien-7-one. |
| Q: What is the CAS number of sugiol? |
| A: CAS number of sugiol is 511-05-7. |
| Q: What is the English name of sugiol? |
| A: The English name of sugiol is sugiol. |
| Q: What is the boiling point of sugiol? |
| A: Boiling point of sugiol is 437.2±45.0 °C at 760 mmHg. |
| Q: What is the SMILES notation of sugiol? |
| A: SMILES notation of sugiol is CC(C)c1cc2c(cc1O)C1(C)CCCC(C)(C)C1CC2=O. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |