12-Hydroxyabieta-8(14),9(11),12-trien-7-one

Modify Date: 2025-08-20 10:38:07

12-Hydroxyabieta-8(14),9(11),12-trien-7-one structure	Common Name	12-Hydroxyabieta-8(14),9(11),12-trien-7-one
	CAS Number	511-05-7	Molecular Weight	300.435
	Density	1.0±0.1 g/cm3	Boiling Point	437.2±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	186.4±21.3 °C

Use of 12-Hydroxyabieta-8(14),9(11),12-trien-7-one

Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].

Name	sugiol
Synonym	More Synonyms

Description	Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ERK1 ERK2 p38 MAPK JNK1 JNK2 IL-1β
In Vitro	Sugiol (5-30 μM; 30 min) 抑制 J774A 细胞中 TNF-α 和 proIL-1β/IL-1β 蛋白的产生[1]。 Sugiol (5-30 μM; 30 min) 在脂多糖诱导的 J774A 细胞中抑制 MAPK 激活，抑制 ERK1/2, JUNK1/2 和 p38 磷酸化[1]。 Western Blot Analysis[1] Cell Line: J774A.1 macrophages cells stimulated with LPS Concentration: 5 μM, 10 μM, 20 μM, and 30 μM Incubation Time: 30 min Result: Completely inhibited ERK1/2 phosphorylation at 30 μM, and effectively inhibited JNK1/2 and p38 phosphorylation.
References	[1]. Chao KP, et al. Anti-inflammatory activity of sugiol, a diterpene isolated from Calocedrus formosana bark. Planta Med. 2005 Apr;71(4):300-5.

Density	1.0±0.1 g/cm3
Boiling Point	437.2±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₂
Molecular Weight	300.435
Flash Point	186.4±21.3 °C
Exact Mass	300.208923
PSA	37.30000
LogP	6.77
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.539
InChIKey	IPEHJNRNYPOFII-AZUAARDMSA-N
SMILES	CC(C)c1cc2c(cc1O)C1(C)CCCC(C)(C)C1CC2=O

Hazard Codes	Xi

Name: Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3095729

Name: Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3095730

Name: Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Source: ChEMBL
Target: HL-60
External Id: CHEMBL3095731

Name: Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Source: ChEMBL
Target: PC-3
External Id: CHEMBL3095732

Name: Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Source: ChEMBL
Target: A549
External Id: CHEMBL3095733

Name: Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 4...
Source: ChEMBL
Target: MCF7
External Id: CHEMBL4812858

Name: Growth inhibitory activity against human MDA-MB-231 breast tumor cell line
Source: ChEMBL
Target: MDA-MB-231
External Id: CHEMBL824960

Name: Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Source: ChEMBL
Target: K562
External Id: CHEMBL4316824

Name: Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Source: ChEMBL
Target: MIA PaCa-2
External Id: CHEMBL1816555

Name: Inhibitory activity against human A549 lung tumor cell proliferation
Source: ChEMBL
Target: A549
External Id: CHEMBL836377

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12-Hydroxyabieta-8,11,13-triene-7-one

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12-hydroxy-abieta-8,11,13-trien-7-one

12-Hydroxyabieta-8(14),9(11),12-trien-7-one

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12-hidroxyabieta-8,11,13-trien-7-one

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China
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
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Price: ￥4640.0/5mg
Purity: 98.0%
Delivery: 3 Day
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naturewill
China
Product Name: 12-Hydroxyabieta-8(14),9(11),12-trien-7-one
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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