Amentoflavone-4',4",7-trimethyl Ether

Modify Date: 2025-08-20 12:16:25

Amentoflavone-4',4",7-trimethyl Ether Structure
Amentoflavone-4',4",7-trimethyl Ether structure
Common Name Amentoflavone-4',4",7-trimethyl Ether
CAS Number 521-34-6 Molecular Weight 580.538
Density 1.4±0.1 g/cm3 Boiling Point 839.6±65.0 °C at 760 mmHg
Molecular Formula C33H24O10 Melting Point 296-298ºC
MSDS N/A Flash Point 276.2±27.8 °C

 Use of Amentoflavone-4',4",7-trimethyl Ether


Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].

 Names

Name sciadopitysin
Synonym More Synonyms

 Amentoflavone-4',4",7-trimethyl Ether Biological Activity

Description Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].
Related Catalog
Target

NF-κB

In Vitro Sciadopitysin (2.5, 5, 10 μM ) strongly reduces RANKL-induced osteoclast-specific genes expression, including cathepsin K (CTSK), tartrate-resistant acid phosphatase (TRAP) and MMP-9. Furthermore, Sciadopitysin apparently attenuates RANKL-increased expressions of c-Fos and NFATc1[2].
In Vivo Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2].
References

[1]. Briançon-Scheid F, et al. HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba. Planta Med. 1983 Dec;49(12):204-7.

[2]. Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents boneloss in LPS-treated mice. Int Immunopharmacol. 2017 Aug;49:109-117. 

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 839.6±65.0 °C at 760 mmHg
Melting Point 296-298ºC
Molecular Formula C33H24O10
Molecular Weight 580.538
Flash Point 276.2±27.8 °C
Exact Mass 580.136963
PSA 148.80000
LogP 5.50
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.684

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
HS Code 29329990

 Synonyms

Amentoflavone-4',4",7-trimethyl Ether
I-7,I-4',II-4'-tri-O-methylamentoflavone
Amentoflavone-7,4',4'''-trimethyl ether
5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-chromen-4-one
Sciadopitysin
5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-
Sciadopytissin
Jin Song biflavone
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here





Get all suppliers and price by the below link:

Amentoflavone-4',4",7-trimethyl Ether suppliers


Price: ¥2275/5mg

Reference only. check more Amentoflavone-4',4",7-trimethyl Ether price