1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one

Modify Date: 2025-08-21 01:43:16

1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one structure	Common Name	1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one
	CAS Number	53948-10-0	Molecular Weight	309.316
	Density	1.3±0.1 g/cm3	Boiling Point	462.8±45.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₅NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	233.7±28.7 °C

Use of 1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one

Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].

Name	1,2,9-Trimethoxydibenzo[cd,f]indol-4(5H)-one
Synonym	More Synonyms

Description	Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Research Areas >> Inflammation/Immunology
References	[1]. Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695.

Density	1.3±0.1 g/cm3
Boiling Point	462.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₅NO₄
Molecular Weight	309.316
Flash Point	233.7±28.7 °C
Exact Mass	309.100098
PSA	60.28000
LogP	3.23
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.681

HS Code	2933990090

4-bromo-5,6-dim...

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5-Methoxy-2-for...

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~80%

1,2,9-Trimethox...

CAS#:53948-10-0

Literature: Choi, Young Lok; Kim, Joa Kyum; Choi, Sang-Un; Min, Yong-Ki; Bae, Myung-Ae; Kim, Bum Tae; Heo, Jung-Nyoung Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3036 - 3040

(E)-N-(4'-metho...

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~36%

1,2,9-Trimethox...

CAS#:53948-10-0

Literature: Estevez, Juan C.; Estevez, Ramon J.; Castedo, Luis Tetrahedron, 1995 , vol. 51, # 39 p. 10801 - 10810

2-bromo-4,5-dim...

CAS#:128604-36-4

1,2,9-Trimethox...

CAS#:53948-10-0

Literature: Estevez; Guitian; Villaverde; Castedo Tetrahedron Letters, 1989 , vol. 30, # 42 p. 5785 - 5786

2-(2-bromo-4,5-...

CAS#:128580-97-2

1,2,9-Trimethox...

CAS#:53948-10-0

Literature: Estevez; Guitian; Villaverde; Castedo Tetrahedron Letters, 1989 , vol. 30, # 42 p. 5785 - 5786

4-Methoxyphenyl...

CAS#:55-81-2

1,2,9-Trimethox...

CAS#:53948-10-0

Literature: Estevez; Guitian; Villaverde; Castedo Tetrahedron Letters, 1989 , vol. 30, # 42 p. 5785 - 5786

Precursor 3
CAS#:1042722-42-8 4-bromo-5,6-dim... CAS#:40138-18-9 5-Methoxy-2-for... CAS#:55-81-2 4-Methoxyphenyl...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%